Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
propylene oxide
IUPAC Name:
propylene oxide
Constituent 2
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
IUPAC Name:
2-methyloxirane

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Following repeated daily oral doses by gavage in 5 rats per sex per goups (18 doses in 24 days), a slight reduction in body weight gain, gastric irritation and slight liver damage were observed at 300 mg/kg. No effect was noted at 100 or 200 mg/kg (Rowe et al., 1956).

Dunkelberg (1982) administered 0, 15 and 60 mg/kg propylene oxide by gavage, twice weekly for 150 weeks to groups of 50 female Sprague-Dawley rata. Survival of the propylene oxide-treated animals did not differ significantly from vehicle controls. The principal findings were reactive changes (epithelial hyperplasia) in the squamous epithelium and associated neoplasms of the forestomach.