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EC number: 247-952-5 | CAS number: 26741-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given - Test substance was tested in a mixture of 3 further substances.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Repeated Insult Patch Test with human volunteers.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,9-bis(2,4-di-tert-butylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- EC Number:
- 247-952-5
- EC Name:
- 3,9-bis(2,4-di-tert-butylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- Cas Number:
- 26741-53-7
- Molecular formula:
- C33H50O6P2
- IUPAC Name:
- 3,9-bis(2,4-di-tert-butylphenoxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
- Details on test material:
- Test substance (CAS 26741-53-7) tested in a mixture of 3 further substances.
No further data provided.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 200
- Sex: 1/3 males and 2/3 females
- Age: 2 - 65 - Controls:
- none
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
The test materials were applied under occlusion for a series of effective contact periods of two days duration, i.e., Monday to Wednesday and Wednesday to Friday of each week for four weeks. On Mondays, the test materials were applied. On Wednesdays the patches were removed, the contact sites examined and the test materials reapplied for another 48 hour period. On Fridays, the covers were removed and the contact sites were again examined and graded. The contact sites were then rested until the following Monday. A mixture of the group of four materials was applied to a single predesignated contact site which was reserved for this specific group throughout the test. On each application day, 4% aqueous solutions were freshly made. Fifty mL of the solutions of each of the four test materials comprising each group were then mixed together and one mL was pipetted off to saturate a lintine disc, 1.25 inch in diameter. One such disc was placed intimately in contact with the contact site on each participant and covered with a water impermeable sheet of plastic (1.5 in. x 1.5 in.). The plastic was then affixed to the skin with Blenderm tape applied in such a manner so as to seal the edges and maintain the integrity of the micro-climate under the patch. On the second Monday following the removal of the last series of applications, each contact site was challenged with its corresponding composite of test materials. The covers were removed on Wednesday, thereby effecting a challenge contact period of 48 hours duration. The contact sites were examined for visible changes which, if present, were graded and recorded. Sites were re-examined 24 and 48 hours later for delayed reactions. At all reading periods, it was found useful to wash the sites in order to remove the dyestuffs obscuring the underlying skin. Satisfactory washing was accomplished with the use of warm water and mild, gentle sponging. In those participants showing visible skin changes typical of irritation resulting from the application of the composite, an additional evaluation was undertaken to determine the particular offending material or materials.
Results and discussion
- Results of examinations:
- No visible skin changes signifying reaction to injury were observed in any of the subjects during the first, second, fourth, fifth and eighth applications.
Third Application - 2 Day's Duration (Second Week)
Visible skin changes signifying reaction to injury were observed in the following two subjects: # 17 (2+) and # 121 (2+). These showed no contraindication to continuation after change of site.
Sixth Application - 2 Day's Duration (Third Week)
Visible skin changes signifying reaction to injury were observed in subjects 26 who showed a 2+ reaction. There appeared to be no contraindication to continuation after change of site.
Seventh Application - 2 Day's Duration (Fourth Week)
Visible skin changes signifying reaction to injury were observed in the following two subjects: # 51 (2+) and #121 (2+). These showed no contraindication to continuation after change of site.
Challenge Application:
No visible skin changes signifying reaction to injury were observed in any of the subjects.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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