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Diss Factsheets
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EC number: 204-514-8 | CAS number: 122-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study following principles similar to those of OECD TG 402
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4'-methylacetophenone
- EC Number:
- 204-514-8
- EC Name:
- 4'-methylacetophenone
- Cas Number:
- 122-00-9
- Molecular formula:
- C9H10O
- IUPAC Name:
- 1-(4-methylphenyl)ethanone
- Details on test material:
- - Name of test material (as cited in study report): RIFM-UF-P70
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 2.50-3.10 kg
- Fasting period before study: no
- Housing: individually in hanging rabbit cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least seven days prior to testing
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: backs
- % coverage: 30 % of the total body surface area
- Type of wrap if used: impervious plastic sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): all residual test material was removed
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0 g/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 2.0 g/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily and initial and final body weights were recorded
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animal died during the observation period of 14 days.
- Clinical signs:
- No untoward behavioral reactions were exhibited by any of the animals following dermal exposure to the samples of fragrance raw material.
- Gross pathology:
- No gross pathologic alterations were noted.
- Other findings:
- - Other observations: Pale red erythema and slight edema were noted after 24 hours. By seven days, dryness was evident. Dryness persisted to the end of the 14-day observation period.
Any other information on results incl. tables
Test material: RIFM-UF-P70
Acute Dermal Toxicity – Albino Rats
Mortality and Body Weight Data
Dose (g/kg) |
Animal Number and Sex |
Individual Body Weight (kg) Test Day Number: |
Number Dead/Number Tested |
Percent Dead |
|
0 |
14 |
||||
2.0 |
1-M |
2.60 |
2.82 |
0/4 |
0 |
2-M |
3.10 |
3.50 |
|||
3-F |
2.84 |
2.78 |
|||
4-F |
3.04 |
3.22 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was acutely non toxic to rabbits in an acute dermal toxicity test with an LD50 value >2.0 g/kg bw. The substance is not classified according to CLP.
- Executive summary:
The acute dermal toxicity of the test substance 4'-methylacetophenone was studied in a non-GLP test according to principles slightly deviating from those of current guidelines. Group of four animals (two males and two females) was exposed to single dermal dose of 2.0 g/kg bw. Animals were observed during a period of 14 days. No mortality was observed under this dosing regime. The LD50 value was calculated as >2.0 g/kg bw. Local skin reactions were pale red erythema and slight edema after 24 hours, as well as dryness, which persisted to the end of the 14 -day observation period.
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