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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Specific investigations
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- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 November 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- GLP study, conducted to current guidelines.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Further details in any other information on materials
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Substance name RED HF2
Substance type UVCB substance
CAS No. Confidential
Batch No. SR164:1
Purity 100% (UVCB)
Appearance Dark red solid (see certificate of analysis)
Test substance storage Ambient conditions but protected from temperatures below 5°C
Stability under storage Stable under recommended storage conditions
Manufacturing date 12 July 2022
Expiry date 12 July 2027 - Key result
- Water solubility:
- 0.284 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1.34 g/L
- Incubation duration:
- 1 h
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not specified.
- Key result
- Water solubility:
- 0.284 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1.64 g/L
- Incubation duration:
- 2 h
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not specified
- Details on results:
- Before introducing the glass beads coated with the test item into the column, approximately 100 mg of glass beads were samples in order to check for the presence of an excess of test item at the beginning of the experiment. They were then extracted with 10 mL of acetone for an HPLC/DAD analysis. The results are presented in any other information on results.
Both systems were considered as in excess of test item since the water solubility estimated is around 1 mg/L
The table in any other information on results presents the concentrations (in mg/L) obtained during the study for both flow rates:
These concentrations are presented as a function of time in illustrations
Some studies have observed higher initial concentrations in the water leaving the column, likely due to loose crystals detaching from the column. The concentrations, however, decreased with recirculation of the water through the column, during which, the detached crystals were most likely retained in the column (6).
The pH controlled with the indicator strips was 5 for all specimen.
The turbidity at the end of the experiment was to 4.67 NFU for the first flow rate and to 2.02 NFU for the second one, meaning that no colloidal matter was present in the water.
The temperature variations were included in the range 19.8°C - 20.1°C.
Equilibrium demonstration
The equilibrium was declared on January 18, 2023 at 11:30 for the first flow rate and on January 20, 2023 at 11:30 for the second flow rate. The following table demonstrates that the equilibrium criteria were valid for each flow rate:
Equilibrium demonstration
The equilibrium was declared on January 18, 2023 at 11:30 for the first flow rate and on January 20, 2023 at 11:30 for the second flow rate. The table in any other information on resuts demonstrates that the equilibrium criteria were valid for each flow rate:
Water solubility calculation
The means of the five last samples before the equilibrium state declaration for each flow rate were:
- 0.251 mg/L for the first flow rate;
- 0.316 mg/L for the second flow rate.
The difference observed between both determinations is 23%, which proves that an acceptable repeatability is obtained (the OECD 105 acceptability criterion for the maximum difference between two tests by the column elution method is 30%).
The RED HF2 solubility in water is given by the mean of the values obtained for both
vessels: 0.284 mg/L. - Conclusions:
- The RED HF2 solubility in water at 20 ± 0.5 °C, based on the mean of both determinations with the column elution method, was: 0.284 mg/L.
- Executive summary:
Introduction A study was performed to assess the water solubility of the test item RED HF2 by the column elution method.
Methods This method is based on the elution of the test item with water from a micro-column charged with an inert support material (glass beads), previously coated with an excess of the test item.
The water solubility is given by the mass concentration of the eluate when a plateau has been reached as a function of time. The test item concentration was regularly measured by an HPLC-DAD analysis.
Results The RED HF2 solubility in water at 20 ± 0.5 °C, based on the mean of both determinations with the column elution method, was: 0.284 mg/L.
Reference
| First flow rate (23.3 mL/h) | Second flow rate (12 mL/h) |
Amount of glass beads coated with the test item sampled for analysis | 103.0 mg | 109.0 mg |
Concentration found in the 10 mL acetone extract | 302 mg/L | 262 mg/L |
Corresponding amount of test item in the system (for 2.5 g of glass beads) | 74.1 mg | 60.4 mg |
Amount lost during the column washing | 0.0903 mg | 0.0585 mg |
Remaining test item amount in the system | 74.0 mg | 60.3 mg |
Theoretical maximum concentration that can be achieved (system volume = 45 mL) | 1.64 g/L | 1.34 g/L |
Sampling date | First flow rate 23.3 mL/h | Second flow rate 12 mL/h |
01/12/23 8:45 | 0.574 | 1.34 |
01/12/23 13:15 | 0.573 | 1.34 |
01/13/23 9:00 | 0.400 | 1.01 |
01/13/23 13:15 | 0.372 | 1.13 |
01/16/23 7:50 | 0.238 | 0.551 |
01/16/23 11:15 | 0.248 | 0.520 |
01/17/23 7:45 | 0.264 | 0.502 |
01/17/23 11:30 | 0.261 | 0.473 |
01/18/23 7:30 | 0.244 | 0.334 |
01/18/23 11:30 | 0.239 | 0.319 |
01/19/23 7:30 | 0.266* | 0.334 |
01/19/23 11:30 | 0.251* | 0.336 |
01/20/23 8:15 | 0.225* | 0.291 |
01/20/23 11:30 | 0.222* | 0.300 |
The values marked * were nor used for the equilibrium determination.
Criteria | First flow rate | Second flow rate |
Maximum difference observed in the 5 last samples Must be < 30% | Min: 0.239 mg/L Max: 0.264 mg/L Difference: 9.9% | Min: 0.291 mg/L Max: 0.336 mg/L Difference: 14.4% |
Conclusion | Equilibrium reached | Equilibrium reached |
Description of key information
The RED HF2 solubility in water at 20 ± 0.5 °C, based on the mean of both determinations with the column elution method, was: 0.284 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.284 mg/L
- at the temperature of:
- 20 °C
Additional information
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