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EC number: 952-715-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Summary of results:
OECD Number |
Study |
Result |
Classification |
OECD 105 |
Water Solubility |
>49.4 w/w of solution |
Cat 1 Acute Cat 1 Chronic
|
OECD 201 |
Algal growth Inhibition |
ERC50 0.027 mg/L NOEC 0.0013 mg/L |
|
OECD 202 |
Acute Daphnia Inhibition |
EC50 0.34 mg/L |
|
OECD 301 F |
Ready Biodegradability |
0% biodegradation after 28 days |
Ready Biodegradability
Available Study: OECD Guideline for Testing of Chemicals (1992) No. 301F, “Ready Biodegradability; Manometric Respirometry Test”.
An initial test conducted at a test concentration of 100 mg/L was terminated after 13 days as the toxicity control had attained 0% biodegradation thereby indicating that it would not pass the validation criterion whereby this vessel needs to attain at least 25% biodegradation by Day 14 of the test for the test item to be considered non-inhibitory.
A second test was conducted which also showed that the toxicity control attained 0% biodegradation after 14 and 28 days which confirmed that the test item was demonstrating an inhibitory effect on the sewage treatment micro-organisms used in the test. Therefore, to try to minimize any inhibitory effects of the test item, the definitive test conducted at a reduced test item concentration of 30 mg/L was exposed to sewage treatment microorganisms with mineral medium in sealed culture vessels in diffuse light at temperatures of between approximately 21 and 22 ºC for 28 days.
The test item attained 0% biodegradation after 28 days and therefore cannot be considered readily biodegradable under the strict terms and conditions of OECD Guideline No. 301F.
Additionally, the toxicity control attained 0% biodegradation after 14 and 28 days thereby, not passing the validation criterion of attaining at least 25% biodegradation by Day 14 of the test for the test item not to be considered to be demonstrating an inhibitory effect. Care should therefore be taken in the interpretation of this result. No conclusion on the degradability of the substance can be made.
Daphnia Magna
Available Study: OECD Guideline for Testing of Chemicals (April 2004) No 202, "Daphnia sp., Acute Immobilisation Test".
Following a preliminary range-finding test, 4 replicates of 5 animals were exposed to aqueous solutions of the test item at nominal concentrations of 0.10, 0.18, 0.32, 0.56 and 1.0 mg/L for 48 hours at a temperature of approximately 19 oC to 21 oC under semi-static test conditions. The number of immobilized Daphnia was recorded after 24 and 48 hours.
Analysis of the freshly prepared test solutions at 0 and 24 hours showed measured test concentrations to range from 89% to 105% of nominal. Analysis of the corresponding aged test solutions at 24 and 48 hours showed a concentration dependent decline in measured test concentrations in the range of 18% to 76% of nominal indicating that the test item was unstable under the conditions of the test. Given this decline in measured test concentrations it was considered justifiable to base the results on the geometric mean measured test concentrations in order to give a "worst case" analysis of the data. The geometric mean measured test concentrations were determined to be 0.042, 0.085, 0.14, 0.36 and 0.80 mg/L.
Exposure of Daphnia magna to the test item gave the following results:
Time Point (Hrs) |
EC50 (mg/L) |
95% confidence Limits (mg/L) |
No Observed Effect Concentration (NOEC) (mg/L) |
Lowest Observed Effect Concentration (LOEC) (mg/L) |
48 |
0.34 |
Not determinable |
0.14 |
0.36 |
Given the substance should not be readily hydrolysed in water, and the nominal concentrations in aqueous solution were <1 mg/L, the substance fulfils the criteria for classification as Category 1 Acute Aquatic Toxicity, per CLP, Annex I, Section 4.1, Table 4.1.0.
Green Algae
Available study: OECD Guideline for Testing of Chemicals(2006) No 201, "Freshwater Alga and Cyanobacteria, Growth Inhibition Test".
Following preliminary range-finding tests and an initial experiment, Raphidocelis subcapitata was exposed to aqueous solutions of the test item at nominal concentrations of 0.00625, 0.0125, 0.025, 0.050 and 0.10 mg/L (three replicate flasks per concentration) for 72 hours, under constant illumination and shaking at a temperature of 24 ± 1 °C. Due to the nature of the test the study was conducted with no media renewal (static). Growth was observed to be reduced by >50% at 0.05mg/L (56%)
Analysis of the test preparations at 0 hours showed measured test concentrations to range from less than the limit of detection (LOD) of the analytical method employed, determined to be 0.0025 mg/L, to 0.037 mg/L. A decline in measured test concentrations was observed to less than the LOD in all test preparations at 24 and 48 hours, and from less than the LOD to 0.0074 mg/L at 72 hours. These results indicate that the test item was unstable under the conditions of the test.
Given this decline in measured test concentrations it was considered justifiable to base the results on the geometric mean measured test concentrations in order to give a "worst case" analysis of the data. The geometric mean measured test concentrations were determined to be 0.0013, 0.0017, 0.0019, 0.0021 and 0.0045 mg/L. Exposure of Raphidocelis subcapitata to the test item gave the following results based on the geometric mean measured test concentrations:
Response Variable |
Endpoint |
Measured Concentration |
95% Confidence Limits (mg/L) |
Growth Rate
|
ErC10 |
0.0011 |
0.00042-0.0014 |
ErC50 |
0.0027 |
0.0022-0.0040 |
|
NOEC |
0.0013 |
N/A |
Given the substance is not readily biodegradable, should not be easily hydrolysed in water, and even taking nominal concentrations a greater than 50% reduction was observed at <0.1mg/L, the substance fulfils the criteria for classification as Category 1 Acute Aquatic Toxicity and Category 1 Chronic Aquatic toxicity per CLP, Annex I, Section 4.1, Table 4.1.0.
Additional information
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