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EC number: 219-702-5
CAS number: 2500-88-1
The dispositon of Hostanox SE 10 was investigated in male Wistar rats
after single oral doses of 100 and 1000 mg/kg bw. A dose-dependent
increase in blood concentration of Hostanox SE 10 was observed and
Hostanox SE 10 was cleared from blood within a parent half-life of 14
hours. Maximum blood concentrations of Hostanox SE 10 were reached
within 6 hours and were 250 pmol/mL blood. Low concentrations of the
test item were also observed in liver, kidney and mesentheric
lymphnodes. The data indicate that Hostanox SE 10 absorption from the
gastro-intestinal tract is very limited after oral administration and
that the absorbed amount of the substance is rapidly cleared from blood.
Most of the administered dose (93 +/- 14 %) was recovered in feces
within 72 h supporting the observed low bioaccessibility.
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