Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-702-5
CAS number: 2500-88-1
Dioctadecyl disulphide applied by gavage to rats was mainly excreted via feces (range: 87.7 - 93 %) indicating a very limited bioaccessibility.Half-life in blood was from 9.6 to 14 hours. Low concentrations of the test substance were found in mesentheric lymph nodes, kidneys and liver.
The dispositon of Hostanox
SE 10 was investigated in male Wistar rats after single oral doses of
100 and 1000 mg/kg bw. A dose-dependent increase in blood concentration
of Hostanox SE 10 was observed and Hostanox SE 10 was cleared from blood
within a parent half-life of 14 hours. Maximum blood concentrations of
Hostanox SE 10 were reached within 6 hours and were 250 pmol/mL blood.
Low concentrations of the test item were also observed in liver, kidney
and mesentheric lymphnodes. The data indicate that Hostanox SE 10
absorption from the gastro-intestinal tract is very limited after oral
administration and that the absorbed amount of the substance is rapidly
cleared from blood. Most of the administered dose (93 +/- 14 %) was
recovered in feces within 72 h supporting the observed low
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again