Registration Dossier
Registration Dossier
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EC number: 201-126-0 | CAS number: 78-59-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is with high probability acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 145 mg/L
Additional information
Experimental data are available for the assessment of the short-term toxicity of isophorone to fish. In a Publication of Cairns and Nebeker (1982) the cute toxicity of the substance was assessed with a short-term toxicity test, conducted according to US EPA EPA-660/3-75-009 (1975). Pimephales promelas was a test organism in this study. The 96-h LC50 was determined to be 145 mg/L (measured, Cairs and Nebeker, 1982).
Additionally, under supervision of the Japanese Ministry of the Environment a limit acute fish test according to OECD 203 was conducted under GLP and published in 1996. The test species was Oryzias latipes. The fish were exposed for 96 hours under semi-static conditions to nominal test concentrations of 100 mg/L. The test concentrations were analytically verified. The 96-h LC50 was determined to be higher than the highest test concentration of 100 mg/L (measured, NITE, 1992).
Therefore, it can be concluded, that the substance is with high probability acutely not harmful to fish.
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