Registration Dossier
Registration Dossier
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EC number: 245-740-7 | CAS number: 23564-05-8
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Acute toxicity to honeybees (contact, 48h): LD50 > 100 µg/bee
Acute toxicity to honeybees (oral/contact, 48h): LD50 > 114.68 µg formulated product/bee/ LD50 > 100 µg a.i./bee (LD50 > 273.4 µg formulated product/bee/ LD50 > 238.4 µg formulated product/bee)
Chronic toxicity to honeybees (10d): NOED > 48.26 µg/bee/day.
Key value for chemical safety assessment
Additional information
Toxicity to Bees: Toxicity data have been provided addressing acute and long-term toxicity to honeybees of the test item. The following endpoints have been used to address the risk assessment:
Acute toxicity to honeybees: One study (consisting of contact route of exposure, with the test item) is available, performed on the honey bee Apis mellifera and concluded as acceptable for use in the risk assessment. The critical endpoints are a 48 hour oral LD50 of >100 µg/bee.
Source: Thiophanate-methyl - Honey bee acute contact LD50, Yamada, T. and Matsuda, M., 1986.
Acute toxicity to honeybees: A single study (consisting of oral and contact routes of exposure) with the active substance is available, performed on the honeybee Apis mellifera L. and concluded as reliable. This study provides additional information as the risk assessment scheme for honeybees has not been formally adopted yet. The endpoints are 48 hour oral/contact LD50 > 114.68 µg a.i./bee/ LD50 > 100 µg a.i./bee (corresponding to LD50 > 273.4 µg formulated product/bee/ LD50 > 238.4 µg formulated product/bee).
Source: Assessment of Side Effects of BAS 325 11 F to the Honey Bee, Apis mellifera L. in the Laboratory, Kling A. 2005.
Chronic toxicity to honeybees: A single study with the active substance is available, performed on the honeybee Apis mellifera. It was concluded to be reliable. This study provides additional information as the chronic risk assessment scheme for honeybees has not been formally adopted yet. The endpoint is a 10 day chronic NOED of ≥ 48.26 μg a.i./bee/day.
Source: Chronic Oral Toxicity Test of Thiophanate-methyl on the Honey Bee (Apis mellifera L.) in the Laboratory, Taenzler V. and Muenz J, 2015.
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