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EC number: 949-986-2
CAS number: 49720-39-0
L-arginine phosphate monohydrate has been characterized by thermal
analysis as advised in OECD Guideline 102, point 8, Table 1, aiming to
determine its melting point and facilitate calculation of vapour
pressure. The presented results clearly demonstrate that L-arginine
phosphate monohydrate decomposes in three distinct stages between
approximately 125 °C – 400 °C (see Figure 1 and Figure 2) rather than
display specific melting points. Hence, a melting point cannot be
determined due to decomposition.
Decomposition also means the crystalline compound has no vapour pressure
that can be determined as mentioned in Guideline 104, point 3. The high
temperature and energy required for decomposition of the compound and
the lack of a mass loss prior to this decomposition suggests that
L-arginine phosphate monohydrate displays similar properties as the
closely related compounds L-arginine (CAS No. 74-79-3) and
L-arginine·HCl (CAS No. 1119-34-2), reported as ≤ 0 mm Hg at 25 °C. The
vapour pressure for L-arginine phosphate monohydrate can therefore be
expected to be ≤ 0 mm Hg at 25°C.
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