Registration Dossier
Registration Dossier
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EC number: 212-379-1 | CAS number: 812-00-0
Endpoint summary
Administrative data
Description of key information
Oral route: Following a single oral dose of 2.0 g/kg bw test material, the LD50 was found to be > 2.0 g/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Single dose of 2.0 g/kg bw
- No. of animals per sex per dose:
- Five males and five females
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female died on study Day 2
- Clinical signs:
- other: Piloerection, abnormal body carriage (hunched posture, abnormal gait (waddling), lethargy, decreased respiratory rate, partially closed eyelids, apllor of extremities, increased salivation, noisy respiration and walking on toes. Recovery was complete by D
- Gross pathology:
- No abnormalities noted at macroscopic examination.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was found to be > 2.0 g/kg bw.
- Executive summary:
Following a single oral dose of 2.0 g/kg bw test material, the LD50 was found to be > 2.0 g/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Dermal route
The study need not be conducted because the substance is classified as corrosive to the skin.
Inhalation route
The study need not be conducted because the substance is classified as corrosive to the skin.
Justification for classification or non-classification
The LD50 value reported following oral administration of the substance was > 2000 mg/kg bw and classification under the criteria given by Regulation EC No. 1272/2008 is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
