Registration Dossier
Registration Dossier
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EC number: 245-396-8 | CAS number: 23047-25-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: secondary source
- Title:
- HSDB: LOFEPRAMINE
Materials and methods
Test material
- Reference substance name:
- Lofepramine
- EC Number:
- 245-396-8
- EC Name:
- Lofepramine
- Cas Number:
- 23047-25-8
- Molecular formula:
- C26H27ClN2O
- IUPAC Name:
- 2-[(3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)(methyl)amino]-1-(4-chlorophenyl)ethan-1-one
- Details on test material:
- Details on test material are not available since coming from a secondary source
Constituent 1
- Specific details on test material used for the study:
- Details on test material are not available since coming from a secondary source
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Details on dermal exposure:
- The substance was administered by subcutaneous route.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- data from subcutaneus administration
- Effect level:
- > 1 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Executive summary:
LD50 Mouse sc >1000 mg/kg
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