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EC number: 817-187-7 | CAS number: 1803088-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-05-08 to 2017-06-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5,7-Di-t-butyl-3-[3,5-dimethyl-4-[(1,3,7,9-tetra-t-butyl-5-methyl-5H-benzo[d][1,3,2]benzodioxaphosphocin-11-yl)oxy]phenyl]-3H-benzofuran-2-one
- EC Number:
- 817-187-7
- Cas Number:
- 1803088-15-4
- Molecular formula:
- C54 H73 O5 P
- IUPAC Name:
- 5,7-Di-t-butyl-3-[3,5-dimethyl-4-[(1,3,7,9-tetra-t-butyl-5-methyl-5H-benzo[d][1,3,2]benzodioxaphosphocin-11-yl)oxy]phenyl]-3H-benzofuran-2-one
- Details on test material:
- - State of aggregation: Solid / white
- Storage Condition: room temperature under light exclusion
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: GSID 1212253-1 OP3
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: test substance was weighed and placed in a culture bottle and then a fixed amount of mineral medium or purified water was added. It was confirmed that the pH of the test solution was 7.0.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Standard activated sludge, purchased from the Chemicals Evaluation and Research Institute (3-2-7 Miyanojin, Kurume, Fukuoka 839-0801, Japan), on April 19, 2017
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium was prepared by adding each 6 mL of stock solution A, B, C and D to 1976 mL of purified water (which was adapted to quality of Japanese Pharmacopeia) and adjusted the pH to 7.0.
Stock solutions for mineral medium
Solution A:
Potassium dihydrogen orthophosphate, KH2PO4 0.85 g
Dipotassium hydrogen orthophosphate, K2HPO4 2.175g
Disodium hydrogen orthophosphate dodecahydrate, Na2HP04• 12H2O, 4.46 g
Ammonium chloride, NH4CI, 0.17 g
Dissolve in water and make up to 100 mL. The pH value of the solution should be 7.2.
Solution B
Magnesium sulphate heptahydrate, MgS04 • 7H2O, 2.25 g
Dissolve in water and make up to 100 mL.
Solution C
Calcium chloride anhydrous, CaCl2, 2.75 g
Dissolve in water and make up to 100 mL.
Solution D
Iron(III) chloride hexahydrate, FeCl3• 6H20, 0.025 g
Dissolve in water and make up to 100 mL. The pH of the solution should be 7.2.
- Test temperature: 25 ± 1°C
TEST SYSTEM
- Culturing apparatus: culture bottle in oxygen consumption analyzer for 28 days
- Number of culture flasks/concentration: 3
- Measuring equipment: oxygen consumption was continuously measured by using a Coulometer (OM-3001 A, Ohkura Electric Co., Ltd.)
CONTROL AND BLANK SYSTEM
- Inoculum blank: 1 bottle, Mineral medium 290 mL + Inoculum 900 mg/L solution 10 mL
- Abiotic control: Test substance (30.00 mg) + Purified water 300 mL
- Activity control: Aniline 29.5 µL (30.12 mg) + mineral medium 290 mL + Inoculum 900 mg/L solution 10 mL
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 28 d
- Key result
- Parameter:
- % degradation (test mat. analysis)
- Remarks:
- calculated by HPLC analysis
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- The biodegradability of the test substance after 28 days as calculated from the BOD curve were 0%, -1% and 0%, respectively, and the mean biodegradability of test substance was 1%.
The biodegradability of aniline was 61 % after 7 days and 65% after 14 days, and the oxygen consumption curve was normal. Thus, that the degradability activity of the active sludge was normal. The difference of maximum value of the biodegradability and minimum value after 28 days became 1%, and it was under 20%. Therefore, the test was valid.
On the test solution after 28 days culture, the residual concentration of the test substance was measured by the HPLC method. In the abiotic control (test substance + water), the test substance was detected at 101% relative to the amount supplied and in the test suspensions (test substance + sludge) bottles, detected at 101%, 101% and 101%.
BOD5 / COD results
- Results with reference substance:
- The biodegradability of aniline was 61 % after 7 days and 65% after 14 days, and the oxygen consumption curve was normal.
Any other information on results incl. tables
The test was considered valid because:
- the degradation of the reference item at day 7 was >= 40 %.
- the degradation of the reference item at day 14 was >= 65 %.
- The difference of the maximum value of the biodegradability and the minimum value after 28 days became 1%, and it was under 20%.
Table 1: Biodegradability calculated from measured oxygen consumption (moc)
Groups |
Theoretical Oxygen Demand (mg) |
day 7 |
day 14 |
day 21 |
day 28 |
||||
moc [mg] |
Degradability(%) |
moc [mg] |
Degradability (%) |
moc [mg] |
Degradability (%) |
moc [mg] |
Degradability (%) |
||
Test suspensionbottle1 |
81.8 |
3.0 |
-1 |
5.6 |
0 |
6.0 |
0 |
6.0 |
0 |
Test suspension bottle2 |
81.8 |
2.5 |
-1 |
5.4 |
0 |
5.6 |
0 |
5.7 |
-1 |
Test suspension bottle3 |
81.8 |
2.9 |
-1 |
5.6 |
0 |
6.0 |
0 |
6.1 |
0 |
Activity control (Aniline) |
90.6 |
58.5 |
61 |
64.4 |
65 |
66.7 |
67 |
69.3 |
69 |
Inoculum blank |
— |
3.5 |
- |
5.2 |
- |
6.0 |
- |
6.4 |
- |
Abiotic control |
— |
0.0 |
- |
0.0 |
- |
0.0 |
- |
0.0 |
- |
Table 2: Residues of the test substance determined by HPLC
Groups |
Amount supplied (mg) |
Peak areas |
Concentrations calculated by the 2-point calibration (mg/L) |
Residual amount (mg) |
Ratio relative to the amount supplied (%) |
Test suspension bottle 1 |
30.00 |
166465 |
149.4532 |
30.38" |
101 |
Test suspension bottle 2 |
30.00 |
166373 |
149.3706 |
30.36 |
101 |
Test suspension bottle 3 |
30.00 |
165974 |
149.0113 |
30.29 |
101 |
Inoculum blank |
- |
N.D. * |
- |
- |
- |
Abiotic control |
30.00 |
165975 |
149.0116 |
30.44 |
101 |
*Quantification limit: 0.3760 mg/L(1000 as the peak area) or less was indicted as N.D.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
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