Registration Dossier
Registration Dossier
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EC number: 220-816-2 | CAS number: 2906-12-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The delayed contact hypersensivity of 3-isopropoxypropylamine (IPOPA) was evaluated in Guinea pigs according a protocol similar to OECD N°406 guideline (Magnusson and Kligman test) (Manciaux, 1998b). The induction phase has been realized both by intradermal route on day 1 (IPOPA 0.1% in vehicle) and by cutaneous route on day 8 (IPOPA 25%) in 2 groups of guinea pigs: 5 males and 5 females for control group and 10 males and 10 females for treated group. The challenge phase was realized on day 22 by cutaneous application of IPOPA 10%; the cutaneous reactions were scored 24 and 48 hours after the challenge phase. No cutaneous reaction was observed in the animals of the control group. In the treated group, a very slight or well-defined erythema (grade 1 or 2) was noted at the 24hour reading in 6/20 and 13/20 guinea pigs respectively. A slight oedema (grade 2) was recorded in 3/20 animals. At the 48hour reading, a very slight or well-defined erythema (grade 1 or 2) persisted in 5/20 and 1/20 animals respectively. Dryness of the skin was observed in 14/20 animals and crusts were noted in one animal. 3-isoproxypropylamine induces delayed contact hypersensitivity in 65% and should be considered as a strong sensitizing.
Migrated from Short description of key information:
3-Isopropoxyproylamine induces delayed contact hypersensitivity in 65% and should be considered as a strong sensitiser.
Justification for selection of skin sensitisation endpoint:
Key study
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
- According to CLP criteria
Skin sensitizer category 1A, H317: May cause an allergic skin reaction
- According to DSD criteria
Xi, R43: May cause sensitisation by skin contact
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