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EC number: 220-816-2 | CAS number: 2906-12-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- None.
- Vehicle:
- no
- Details on test solutions:
- Test solutions were standard solutions as described in the OECD 202 guideline.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: Clone 5 or Clone A
- Source: Laboratory bred on Elendt M7
- Feeding during test: none
- Food type during parent breeding: Raphidocelis subcapitata
- Age: less than 24-h old
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- No data.
- Test temperature:
- 19-21°C (min - max)
- pH:
- Comprised between 7.9 and 8.7 from 0 to 47 mg/L test concentrations. Comprised between 9 and 9.1 at 75 mg/L. Comprised between 9.4 and 9.7 at 120 mg/L.
- Dissolved oxygen:
- 7.5-8.0 (min-max)
- Salinity:
- Freshwater
- Conductivity:
- No data
- Nominal and measured concentrations:
- Stability of the test item was checked in a previous study on daphnia in the same laboratory. It was demonstrated that the test item is stable. Therefore, nominal concentrations were used and not monitored in the present study: control ; 7.2 ; 11.4 ; 18.4 ; 29.3 ; 46.9 ; 75 and 120 mg/L.
- Details on test conditions:
- TEST SYSTEM
- Type: tightly closed with PTFE septa to avoid evaporation
- Material, size, headspace, fill volume: 120 mL, no headspace
- Aeration: None
- Renewal rate of test solution (frequency/flow rate): no renewal during the test (static test)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Adjustment of pH: none
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mobility at 24 and 48 hours.
RANGE-FINDING STUDY
- Test concentrations: 37 - 200 mg/L
- Results used to determine the conditions for the definitive study: EC50 < 37 mg/L - Reference substance (positive control):
- not required
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 65 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- After 48 hours exposure, immobilisation reached 65% at 75 mg/L and 100% at 120 mg/L. It remained between 0 and 5% (i.e. one daphnid) in the other treatments. As a result, the 48h-EC50 of the test item is considered 65 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- 48h-EC50 of 3-isopropoxypropanamine is 65 mg/L.
- Executive summary:
An OECD 202 study was carried out in order to assess the acute toxicity of 3 -isopropoxypropanamine (IPOPA) to daphnia. Tested concentrations were 0 ; 7.2 ; 11.4 ; 18.4 ; 29.3 ; 46.9 ; 75 and 120 mg/L. Concentrations were not monitored analytically, but stability of the test item was checked in the range-finder. It was demonstrated that the test item is stable. Therefore, nominal concentrations were used and no analytical monitored was deemed necessary. The highest concentration had a pH above 9, which could explain the 100% mortality observed. In the 75 mg/L group, the pH was at the limit of the acceptable for this kind of test (9.0 -9.1). 65% mortality was observed. In the absence of any toxicity testing with neutralized substance, it is difficult to ascertain whether this mortality is due to pH or the substance itself. Giving that the range finder gave an EC50 < 37 mg/L, it is considered that the 65% immobilisation observed at 75 mg/L is not pH related. Therefore, an EC50 can be derived and is equal to 65 mg/L.
Reference
Description of key information
An OECD 202 study was carried out in order to assess the acute toxicity of 3 -isopropoxypropanamine (IPOPA) to daphnia. Tested concentrations were 0 ; 7.2 ; 11.4 ; 18.4 ; 29.3 ; 46.9 ; 75 and 120 mg/L. Concentrations were not monitored analytically, but stability of the test item was checked in the range-finder. It was demonstrated that the test item is stable. Therefore, nominal concentrations were used and no analytical monitored was deemed necessary. The highest concentration had a pH above 9, which could explain the 100% mortality observed. In the 75 mg/L group, the pH was at the limit of the acceptable for this kind of test (9.0 -9.1). 65% mortality was observed. In the absence of any toxicity testing with neutralized substance, it is difficult to ascertain whether this mortality is due to pH or the substance itself. Giving that the range finder gave an EC50 < 37 mg/L, it is considered that the 65% immobilisation observed at 75 mg/L is not pH related. Therefore, an EC50 can be derived and is equal to 65 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 65 mg/L
Additional information
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