Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-129-8 | CAS number: 2051-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Food Flavorings and Compounds of Related Structure I. Acute Oral Toxicity
- Author:
- P. M. JENNER, E C. HAGAN, JEAN M. TAYLOR, E. L. COOK and O. G. FITZHUGH
- Year:
- 1 964
- Bibliographic source:
- Fd Cosmet. Tex/col Vol. 2 pp. 327-343. Pergamon Press 1964.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- The purpose of this study was to evaluate the toxicity of Allyl butyrate in relation to their use as food additives in Osborne-Mendel rats.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Allyl butyrate
- EC Number:
- 218-129-8
- EC Name:
- Allyl butyrate
- Cas Number:
- 2051-78-7
- Molecular formula:
- C7H12O2
- IUPAC Name:
- prop-2-en-1-yl butanoate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): 2-Propen-1-yl butanoate
- Common name: Allyl butyrate
- Molecular formula: C7H12O2
- Molecular weight: 128.17 g/mol
- Smiles notation: C(OCC=C)(CCC)=O
- InChl: 1S/C7H12O2/c1-3-5-7(8)9-6-4-2/h4H,2-3,5-6H2,1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 2-Propen-1-yl butanoate
- Common name: Allyl butyrate
- Molecular formula: C7H12O2
- Molecular weight: 128.17 g/mol
- Smiles notation: C(OCC=C)(CCC)=O
- InChl: 1S/C7H12O2/c1-3-5-7(8)9-6-4-2/h4H,2-3,5-6H2,1H3
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: Housed individually in wire cages.
- Diet (e.g. ad libitum): food ad libitum
- Water (e.g. ad libitum): water ad libitum
- Acclimation period:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Details on oral exposure
No data available - Duration of treatment / exposure:
- 90 mg/kg/day given for 18 week
50 mg/kg/day given for 17 weeks - Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 50 other: mg/kg/day
- Dose / conc.:
- 90 other: mg/kg/day
- No. of animals per sex per dose:
- 50 mg/kg/day 10 male and 10 female
90 mg/kg/day 10 male and 10 female - Control animals:
- not specified
- Details on study design:
- Details on study design
No data available - Positive control:
- Not specified
Examinations
- Observations and examinations performed and frequency:
- Observations and examinations performed & frequency
CAGE SIDE OBSERVATIONS: No data available.
DETAILED CLINICAL OBSERVATIONS: Yes
BODY WEIGHT: No data available
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data available.
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data available
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data available
OPHTHALMOSCOPIC EXAMINATION: No data available
HAEMATOLOGY: No data available.
CLINICAL CHEMISTRY: No data available
URINALYSIS: No data available
NEUROBEHAVIOURAL EXAMINATION: No data available - Sacrifice and pathology:
- Sacrifice and pathology
GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Statistics:
- No data available.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Clinical signs- Growth retardation was observed in male at dose 90 mg/kg/day.
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Rough and granular surface, firm consistency, nutmeg appearance was observed in liver at 90 mg/kg/day.
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- At 90 mg/kg/day slight to moderate bile duct proliferation and fibrosis with pseudolobule formation .Necrosis with polymorph nuclear infiltration and swollen, foamy liver in 2-8 rats was observed.
At 50 mg/kg/day slight to marked prebrochial lymphocyte infilteration was examined in treated group compare to controls. No effect was observed in liver at 50 mg/kg/day - Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- histopathology: non-neoplastic
- Remarks on result:
- other: No Growth retardation was observed .There was significant microscopic change in lung was observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL was found to be 50 mg/kg for Allyl butyrate in male and female Osborne-Mendel rats for 17 weeks by oral (gavage).
- Executive summary:
Repeated toxicity study forAllyl butyratein male and femaleOsborne-Mendel rats was observed when they were exposed in a concentration of 50 and 90 mg/kg for 17 and 18 week respectively by oral (gavage). Rough and granular surface, firm consistency, nutmeg appearance was observed in liver at 90 mg/kg/day. At 90 mg/kg/day slight to moderate bile duct proliferation and fibrosis with pseudolobule formation .Necrosis with polymorph nuclear infiltration and swollen, foamy liver in 2-8 rats was observed. At 50 mg/kg/day slight to marked prebrochial lymphocyte infilteration was examined in treated group compare to controls. No effect was observed in liver at 50 mg/kg/day. As no significant change were observed on the clinical sign and gross pathology of other organ . Therefore NOAEL was found to be 50 mg/kg/day forAllyl butyrate for chronic study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.