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Diss Factsheets
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EC number: 939-053-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Reverse gene mutation assay in bacteria
In a reverse gene mutation assay in bacteria according to OECD Guideline 471, the strains TA 1535, TA 97a, TA 98, TA 100 and TA 102 of S. typhimurium were exposed to Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid in the presence and absence of mammalian metabolic activation (rat liver S9-mix induced by Aroclor 1254).
Strains were exposed to the test item, diluted in water, at concentrations of 50, 150, 500, 1500 and 5000 µg / plate in the first experiments (1a and 1b) and to 313, 625, 1250, 2500 and 5000 µg/plate in the second experiments (2a and 2b). The first experiments were conducted using the plate incorporation method; in the second experiments the pre-incubation method was used.
In neither of the tests precipitation or signs of toxicity towards the bacteria were observed at any concentration.
There was no evidence of induced mutant colonies over background up to the limit concentration of 5000 µg/plate.
The positive controls induced the appropriate responses in the corresponding strains and activity of metabolic system was confirmed. Values for the spontaneous revertants of the negative controls were in the normal range.
This study satisfies the requirement for Test OECD 471 for in vitro mutagenicity (bacterial reverse gene mutation) data.
The test item Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid, aqueous solution was considered as not mutagenic under the conditions of the test.
Justification for selection of genetic toxicity endpoint
The key study is GLP-compliant and of high quality (Klimisch 1).
Short description of key information:
In vitro data from a bacterial reverse mutation assay (Ames Test) are available for Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
In conclusion, Reaction mass of 1,3-benzene disulfonic acid and sulfuric acid does not need to be classified for germ cell mutagenicity according to GHS Regulation EC No 1272/2008. No labelling is required.
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