Registration Dossier
Registration Dossier
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EC number: 203-254-2 | CAS number: 104-94-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- A study was conducted to evaluate the skin irritation potential of 4- methoxyaniline according to OECD guideline 404 in rabbits
- GLP compliance:
- no
Test material
- Reference substance name:
- p-anisidine
- EC Number:
- 203-254-2
- EC Name:
- p-anisidine
- Cas Number:
- 104-94-9
- Molecular formula:
- C7H9NO
- IUPAC Name:
- 4-methoxyaniline
- Details on test material:
- - Name of test material: 4-methoxyaniline
- Molecular formula: CH3OC6H4NH2
- Molecular weight: 123.15 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Not reported
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Not reported
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Not reported
- Number of animals:
- Not reported
- Details on study design:
- Not reported
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24
- Reversibility:
- no data
- Remarks on result:
- other: Not irritating
- Irritant / corrosive response data:
- Not irritating
- Other effects:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a study for skin irritation according to OECD guideline 404 after 4 hours of dosing of 4-methoxyaniline was not irritating to the rabbit skin.
- Executive summary:
A study was conducted to evaluate the skin irritation potential of 4- methoxyaniline according to OECD guideline 404 in rabbits
The tests chemical was applied to rabbit skin and after 4 hours of dosing effects were observed.
The test chemical was found to be non-irritant to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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