Registration Dossier
Registration Dossier
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EC number: 203-254-2 | CAS number: 104-94-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There is no information available on the absorption, distribution, metabolism and excretion of p-anisidine in humans. The chemical is known to be absorbed into the body by inhalation of its vapor, through the skin and by ingestion. Considering the high water solubility and low partition co-efficient values, the chemical after absorption is likely to be bio-available for further metabolism. Reports also suggest that it leads to blood damage in living organisms. Thus, it is advised to use the chemical p-anisidine with caution.Since no information is available on the absorption, distribution, metabolism and excretion of p-anisidine in humans, bio-accumulation potential cannot be judged based on the available information.
Key value for chemical safety assessment
Additional information
The test substance p-anisidine can be absorbed into the body by inhalation of its vapor, through the skin and by ingestion.This chemical also has a harmonized classification for acute oral, inhalation and dermal toxicity. Considering the high water solubility and low partition co-efficient values, the chemical after absorption shall be bio-available for metabolism. There is no information on the metabolites formed in humans; though in rabbits it is suggested that p-aminophenol & p-methoxy-n-methylaniline are formed. Reports also suggest that it leads to blood damage in living organisms.
However, since no information is available on the absorption, distribution, metabolism and excretion of p-anisidine in humans,bio-accumulation potential cannot be judgedbased on the available information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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