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Diss Factsheets
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EC number: 434-430-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The test substance has a low water solubility value according to the OECD Guidance No. 23 definition (less than 100 mg/L).
The substance has to be considered as a difficult substance to be tested particularly for (i) achieving exposure concentration and (ii) preparing representative media.
The hydrolysis study was not conducted due to the low solubility of the test substance in water (< 0.2 mg/L). In a standard screening biodegradation test (CO2 evolution test), the percentage of biodegradation of test material was determined at 6% based on TCO2 after 28 days of exposure. The test substance does not meet the readily biodegradable criterion. Calculated log Koc values for the test substance were in the 7.4 - 11.55 range; the substance is likely to be of low mobility in soils.
Aquatic bioaccumulation testing was not conducted due to the fact that (i) the known components of the substance (cf. boundary composition) have log Kow values higher than 13 (13.28 to 20.60) and (ii) because of the high insolubility in water of the test substance (<0.1 µg/L). As a result, bioavailability for aquatic organisms is expected to be low. Indeed, the components have molecular weights ranged between 665 and 964 g/mol and log Kow values higher than 13 (13.28, 14.41 and 20.60). According to Lipinksi et al. (1997), a substance with such properties (log Kow > 5 and MW > 500 g/mol) and more than 5 H-bond donors and 10H-bond acceptors is unlikely to cross a biological membrane in amounts sufficient to exert toxic response. Moreover, Dimitrov et al. (2005) showed that substances with log Kow values higher than 10 had BCF values significantly lower (<1000 L/kg) than the threshold of 2000 L/kg ww.
The BCF values predicted on the registered UVCB's constituents by the BCFBAF v3.01 model from EPISUITE software demonstrates these assomptions (see the table below). However, modelling a BCF or BAF value would not provide reliable information since the log Kow of the substance is high (> 6.0), so that there is no longer a relationship between the log Kow and the BCF/BAF.
Compound | SMILES | Molecular weight (g.mol-1) | Log Kow estimation (KOWWIN v1.68) | Experimental Log Kow (KOWWIN database) | Estimated BCF (BCFBAF v 3.01), L/kg ww | Experimental BCF (BCFBAF Arnot Gobas), L/kg ww | Screening B conclusion |
#1 (Parent substance UVCB) / Constituant No.1 | CCCCCCC(O)CCCCCCCCCCC(=O)NCCCCCCNC(=O)CCCCCCCCCCC(O)CCCCCC | 681 | 13.28 | - | 11.19 | 0.8934 | Predicted Not B/vB |
#1 (Parent substance UVCB) / Constituant No.2 | C(CCCCCNC(CCCCCCCCCCC(CCCCCC)O)=O)NC(CCCCCCCCCCCCCCCCC)=O | 665 | 14,4 | - | 3,1 | - | Predicted Not B/vB |
#1 (Parent substance UVCB) / Constituant No.3 | N(C(CCCCCCCCCCC(CCCCCC)O)=O)CCCCCCNC(CCCCCCCCCCC(CCCCCC)OC(=O)CCCCCCCCCCC(CCCCCC)O)=O | 963 | 20.6 | - | 3.1 | - | Predicted Not B/vB |
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