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EC number: 278-585-9 | CAS number: 76994-37-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 was 206 mg/kg bw in rats after an observation period of 14 days.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-10-04 to 1979-01-24
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study but equivalent or similar to OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- other: 9 doses applied
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 15-20 h before application
- Diet: ad libitum, fasting started 15-20 h before application (food: HERILAN MRH-HALTUNG; H.EGGERSMANN KG)
- Water: ad libitum, fasting started 15-20 h before application - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle % (w/v): 50, 10, 6.81, 4.64, 3.26, 2.15, 1.47, 1.0, 0.681
- Amount of vehicle: 10 mL/kg
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg bw in 10 mL - Doses:
- 5000, 1000, 681, 464, 316, 215, 147, 100, 68.1 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing after 2-4 days, 7 and 13 days
- Necropsy of survivors performed: yes
- Other examinations performed: body weight - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 206 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Slope factor: 2.73
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 133 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: recalculated based on dye content of registered substance (ca. 65% w/w) versus tested material (42% w/w)
- Gross pathology:
- In animals that died following observations were made:
The heart showed acute dilatation of the atria and acute passive hyperemia. Fibrinous coatings on the mucosa of the glandular stomach were detected. In some animals lentil-sized areas with considerably thickened, fibrinous coatings with slight adhesion on the side of the serosa were observed. Isolated bloody ulcerations on the mucosa of the glandular stomach were found. The intestines were slightly atonic and contained diarrheal contents. In the lungs moderate acute emphysema was detected.
In animals that were sacrificed after the observation period no organ abnormalities were detected.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 206 mg/kg bw
Additional information
For acute oral toxicity via oral route an experimental study with the test substance was performed (BASF AG, 1979). It was conducted similar to OECD Guideline 401.
The test substance was given to Sprague-Dawley rats. For each dose 5 animals of each sex were treated once and observed for 14 days. The test substance was administered orally by gavage. Nine different doses were tested. After 14 days an LD50 of 206 mg/kg bw was found. Animals that died during the observation period showed a number of alterations in heart, stomach, intestines and lungs. Those included among others acute dilatation of the atria, acute passive hyperemia, fibrinous coatings and isolated bloody ulcerations on the mucosa of the glandular stomach, diarrheal contents and slightly atonic intestines and a moderate acute emphysema in the lung. Animals that survived and were sacrificed after the observation period showed no pathological changes in organs. With regard to the actual test item composition the median lethal dose was recalculated to 133 mg/kg body weight.
Justification for selection of acute toxicity – oral endpoint
Non GLP study but performed equivalent to guideline.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance needs to be classified and labelled as acute tox. cat. 3, H301 "Toxic if swallowed" under Regulation (EC) No 1272/2008, as amended for the sixth time in Directive EC 605/2014
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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