Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-121-3
CAS number: 78-50-2
study was conducted in rabbits to evaluate the acute dermal toxicity of
the read across substance ‘A mixture of: hexyldioctylphosphineoxide;
dihexyloctylphosphineoxide; trioctylphosphineoxide’ in a method
equivalent to the OECD Guideline 402, in compliance with GLP. The back
of each rabbit was clipped with an electric clipper on the day prior to
dosing. The test substance was topically applied to the non-abraded
dorsal skin at a dose level of 2,000 mg/kg bw. The test sites were
wrapped with an occlusive binder consisting of a layer of plastic wrap
and stockinette sleeve held in place with tape. The binders were removed
24 h post-dose administration and the exposure sites gently wiped with
gauze to remove as much non-absorbed test substance as possible. The
observation period after the dermal administration lasted for 14 d.
Mortality and toxicity signs were recorded three times on the day of
dosing and twice daily thereafter. Individual body weight data were
recorded on Days 1 (prior to dose-administration), 8 and 15. All animals
killed at the termination of the study were subjected to gross necropsy.
Under the study conditions, the acute dermal LD50 of the test
substance was found to be >2,000 mg/kg bw in New Zealand White rabbits
(Busch BA, 1986).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again