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Diss Factsheets
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EC number: 202-905-8 | CAS number: 100-97-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The available ecotoxicological studies demonstrate that methenamine is non-toxic at all for aquatic organisms in acute tests for numerous freshwarter and saltwater species.
When reaching the aqueous environment, methenamine is degraded hydrolytically to ammonium and formaldehyde. The rate of hydrolysis is strongly pH-dependent. While the substance is degraded rapidly at acidic pHs, it seems to be more stable to hydrolysis at pHs > 7 and may persist in the water phase for a few days, before being degraded biologically. Since this effect might occur under environmental relevant conditions, a long term exposure of aquatic systems and organisms in theory is possible but not likely. No studies are available concerning the long-term effects on fish and invertebrates. However, the following aspects clearly demonstrate that such data tests are not needed:
- methenamine was shown to be degradable (mainly hydrolysis, but also biodegradation)
- methenamine was non-toxic in the available tests using aquatic organism (up to 100 times above recommended limit concentrations)
- log Pow of -2.18 does not indicate a potential for bioaccumulation
- one degradation product, formaldehyde, is ready biodegradable, the other degradation product, ammonia, is a naturally occurring substance known for many metabolic pathways in organisms. The environmental levels of both due to degradation of methenamine are very low compared to releases from other sources.
Taking these findings together, a long-term exposure of aquatic organisms to ecotoxicological relevant concentrations of methenamine can be excluded. Hence, further information concerning long-term effects on aquatic organisms is dispensable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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