Registration Dossier
Registration Dossier
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EC number: 215-311-9 | CAS number: 1321-12-6
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: As cited in OECD SIDS: Guideline study without detailed documentation. Experimental details missing
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
- Reference Type:
- publication
- Title:
- QSAR for biotoxiction of aromatic compounds
- Author:
- Liu et al
- Year:
- 1 997
- Bibliographic source:
- Chinese Sci Bull 42 (5): 380 - 385
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ISO/DIS 7346/1.2.3
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitrotoluene
- EC Number:
- 202-808-0
- EC Name:
- 4-nitrotoluene
- Cas Number:
- 99-99-0
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- 1-methyl-4-nitrobenzene
- Details on test material:
- - Analytical purity: >= 98%
Constituent 1
Test organisms
- Test organisms (species):
- Carassius auratus
- Details on test organisms:
- TEST ORGANISM
- Common name: gold fish
- Length at study initiation: 30 ± 5 mm
- Feeding during test: none
ACCLIMATION
- Acclimation period:7 d
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48
- Remarks on exposure duration:
- h
Test conditions
- Test temperature:
- 23 ± 1 °C
- pH:
- 7.8
- Dissolved oxygen:
- - Oxygen concentration > 60 % of saturation
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Fill volume: 10 L
- No. of organisms per vessel: 7
TEST MEDIUM / WATER PARAMETERS
- Intervals of water quality measurement: Daily ckeck of oxygen concentration, pH and temeprature
EFFECT PARAMETERS MEASURED: mortality
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 10.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
