Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 257-098-5 | CAS number: 51274-00-1 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77492.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Remarks:
- The immobilisation and other abnormalities in the controls did not exceed 10% by the end of the test. The dissolved oxygen concentration remained above 3 mg/L throughout the exposure period.
- Conclusions:
- For iron hydroxide oxide the observed 48 hour EC50 on Daphnia magna was >/= 100 mg/L. The determination was performed according to OECD Guideline 202.
- Executive summary:
The determination was performed according to OECD Guideline 202 (Currenta 2008).
The Daphnia were exposed to a limit test concentration of nominally 100 mg/L of iron hydroxide oxide dissolved in water. Auxiliaries used to prepare the test media were an ultrasonic bath and a magnetic stirrer.
Observations were made on the swimming ability and the immobilisation rate, respectively, after 24 and 48 hours of exposure. The test item was insoluble in dilution water. Treatment in an ultrasonic bath (1 h) resulted in yellow-brown colouration of the flask content, indicating fine dispersal of the test item. After treatment on a magnetic stirrer for 24 h, the suspension was tested without filtration.
No toxic effects against daphnia were observed at a limit test concentration of 100 mg/L under static conditions.
Reference
The test item was insoluble in water. Treatment in an ultrasonic bath (1 h) resulted in red-brown colouration of the flask content, indicating fine dispersal of the test item. After treatment on a magnetic stirrer for 24 h, the suspension was tested without filtration.
Description of key information
For alpha iron hydroxide oxide the observed 48 hour EC50 on Daphnia magna was >/= 100 mg/L.
Key value for chemical safety assessment
Additional information
Applying read-across to nanosized iron (hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), nanosized iron manganese trioxide is not considered acutely toxic to aquatic invertebrates. Fornano-alpha iron hydroxide oxide yellow, the observed 48-h EC50 value for the immobilization of Daphnia magna is > 100 mg/L, a concentration that is 100-fold above the corresponding OECD test limit.
Table: Acute toxicity of iron (hydr)oxides to aquatic invertebrates
Endpoint |
Test species |
Test results |
Test material/ form |
Reliability: Reference |
Short-term toxicity to aquatic invertebrates |
Daphnia magna |
EC50 (48h): >100 mg/L nominal |
diiron trioxide / powder |
RL2: Neuhahn, 2008 |
Daphnia magna |
EC50 (48h): >100 mg/L nominal |
iron hydroxide oxide yellow / nano, alpha |
RL2: Neuhahn, 2008 |
|
Daphnia magna |
EC0 (48 h): >= 10 g/L nominal |
triiron tetraoxide |
RL2: Caspers, 2000 |
Acute toxicity of iron (hydr)oxide nanoforms to aquatic invertebrates was investigated in a reliable study with nano-alpha iron hydroxide oxide yellow according to OECD 202 (Neuhahn, 2008). Toxic effects to Daphnia magna were not observed at a limit test concentration of 100 mg/L, representing the respective OECD test limit for acute toxicity, under static conditions and an unbounded 48 h EC 50 value of > 100 mg/L (nominal) was derived.
Based on read-across to nanosized iron (hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), available data indicate a low potential for acute toxicity ofnanosized iron manganese trioxideto aquatic invertebrates (see table below).
Supportive information microsized iron (hydr)oxides
For microsized iron (hydr)oxides, the observed 48-h EC50 values for the immobilization of Daphnia magna range from > 100 mg/L to > 10,000 mg/L, a concentration that is 100-fold above the corresponding OECD test limit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.