2-dimethylaminoethyl methacrylate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Non-GLP, no details on test substance incl. purity, 48-hour reading missing, short observation period).

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1980

Reference 2

Reference Type:

publication

Title:

Atochem (1980), Skin and Ocular Irritation test, Consultox Lab: CL80 65:2030

Author:

Atochem

Year:

2003

Bibliographic source:

cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003

Materials and methods

Principles of method if other than guideline:

According to the method described in the Federal Hazardous Substances Labelling Act Regulations, Section 191.11, published in the Federal Register - 29 F.R. 13009, 1964.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-dimethylaminoethyl methacrylate

EC Number:

220-688-8

EC Name:

2-dimethylaminoethyl methacrylate

Cas Number:

2867-47-2

Molecular formula:

C8H15NO2

IUPAC Name:

2-(dimethylamino)ethyl methacrylate

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

No details.

Test system

Type of coverage:

occlusive

Preparation of test site:

other: intact (shaved) and abraded

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

TEST MATERIAL
- Amount applied: 0.5 ml
- Concentration: undiluted

Duration of treatment / exposure:

24 hours

Observation period:

72 hours

Number of animals:

4

Details on study design:

A 0.5 mL sample of the test material was applied to areas of intact and abraded areas of skin. These areas were then occluded with square surgical gauge patches, each measuring 1 inch x 1 inch. After 24 hrs exposure, the patches were removed and the resulting reactions evaluated. The valuation was done again at 72 hrs.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

24/48/72 h

Score:

4

Max. score:

4

Reversibility:

other: not examined

Remarks on result:

other: Observation period too short for a clear conclusion on reversibility.

Remarks:

Only time point 24 and 72 hours were observed.

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

24/48/72 h

Score:

4

Max. score:

4

Reversibility:

other: not examined

Remarks on result:

other: Observation period too short for a clear conclusion on reversibility.

Remarks:

Only time point 24 and 72 hours were observed.

Irritant / corrosive response data:

Severe erythema, oedema and necrosis were exhibited 24 hrs following application. Reactions persisted to 72 hrs. For all animals and for both of
intact skin and abraded skin, maximum score of 4 was marked in the erythema and oedema rating, therefore a Primary Irritation Score of 8.0 was obtained.

Any other information on results incl. tables

Individual skin responses:

 

Rabbit No.	Time (hours)	Intact Skin		Abraded Skin
		Erythema	Oedema	Erythema	Oedema
1	24	4	4	4	4
	72	4	4	4	4
2	24	4	4	4	4
	72	4	4	4	4
3	24	4	4	4	4
	72	4	4	4	4
4	24	4	4	4	4
	72	4	4	4	4
5	24	4	4	4	4
	72	4	4	4	4
6	24	4	4	4	4
	72	4	4	4	4
Mean	24	4	4	4	4
	72	4	4	4	4

Applicant's summary and conclusion

Interpretation of results:

Category 1B (corrosive) based on GHS criteria

Conclusions:

The test material is considered to be corrosive to the skin.