Acetaldehyde

Genetic toxicity: in vivo

Administrative data

Endpoint:

genetic toxicity in vivo

Remarks:

Type of genotoxicity: other: rvaious

Type of information:

other: hazard assessment report

Adequacy of study:

supporting study

Study period:

-2004

Reliability:

other: reliable hazard assessment

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The literature search for the CERI hazard assessment was conducted in April 2002 with the databases including CAS online, HSDB, IRIS, RTECS ,TOXLINE etc. The references were updated when additional information on data source and others were obtained. In April 2004, the status of the risk assessment of acetaldehyde by international organizations was confirmed and any new studies that were critical to determine NOAEL/LOAEL were included in the references.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other: hazard assessment

Title:

Hazard Assessment Report Acetaldehyde

Author:

Chemicals Evaluation and Research Institute (CERI), Japan

Year:

2007

Bibliographic source:

http://www.cerij.or.jp/ceri_en/hazard_assessment_report/yugai_indx_en.htm

Materials and methods

GLP compliance:

not specified

Type of assay:

other: various

Test material

Test material information

Constituent 1

Reference substance name:

Acetaldehyde

EC Number:

200-836-8

EC Name:

Acetaldehyde

Cas Number:

75-07-0

Molecular formula:

C2H4O

IUPAC Name:

acetaldehyde

Test animals

Species:

other: various

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

other: various

Duration of treatment / exposure:

see Table 1

Frequency of treatment:

see Table 1

Post exposure period:

see Table 1

No. of animals per sex per dose:

see Table 1

Results and discussion

Any other information on results incl. tables

Table 1: Genotoxic potential of Acetaldehyde in in vivo genetoxicity assays

 

Test	Species (route)	Concentration^a	Results	Reference
Sex-linked recessive lethal	Drosophila melanogaster (oral)	25,000 ppm	-	Woodruff et al., 1985
Sex-linked recessive lethal	Drosophila melanogaster (i.p.)	22,500 ppm	+	Woodruff et al., 1985
Micronucleus	Rat bone marrow cells (i.p.)	250 mg/kg	+	Wakata et al., 1998
Micronucleus	Rat peripheral blood cells (i.p.)	250 mg/kg	+	Wakata et al., 1998
Micronucleus	CD-1 male mouse bone marrow cells (i.p.)	400 mg/kg	+	Morita et al., 1997
Micronucleus	C57BL/6J×C3H/He mouse early spermatid (i.p.)	375 mg/kg	-	Lahdetie, 1988
Chromosomal aberration	Rat embryo cells (Administration through the amnion (On gestation day 13)	7,800 mg/kg	+	Barilak & Kozachuk, 1983
Sister chromatid exchange	Male C3A mouse bone marrow cells (i.p.)	0.4 µg/animal	+	Obe et al., 1979
Sister chromatid exchange	Chinese hamster bone marrow cells (i.p.)	0.5 mg/kg	+	Korte et al., 1981
Comet	Human lymphocyte (37°C, 1 hourtreatment)	3-100 mM	+	Blasiak et al., 1999
DNA-protein cross-links	Fischer 344 rat nasal mucosa (Inhalation exposure, 6 hours/day, 5 days)	1,000 ppm	+	Lam et al., 1986
Sperm abnormality	C57BL/6J×C3H/He mouse early spermatid (Intraperitoneal 5 times)	250 mg/kg	-	Lahdetie, 1988

a) When a single dose is described, it indicates the lowest positive concentration in the positive result and the highest negative concentration in the negative result.

 

Applicant's summary and conclusion

Conclusions:

Acetaldehyde showed genotoxic activity in vivo.

Executive summary:

Several in vivo experiments are reported for acetaldehyde. All experiments except those with spermatides and Drosophila melangogaster showed genotoxic activity.