Registration Dossier
Registration Dossier
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EC number: 200-836-8 | CAS number: 75-07-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
In summary, oral administration of acetaldehyde to rats for 4 weeks caused slight hyperkeratosis in the forestomach at a dose of 675 mg/kg/day. The NOAEL is 125 mg/kg/day. Inhalation exposure damaged the epithelium of the respiratory tract in rats and hamsters, showing that a target tissue of inhalation exposure to rats and hamsters is the upper respiratory tract. The NOAELs are 150 ppm (270 mg/m3) for rats exposed for 4 weeks and 390 ppm (700 mg/m3) for hamsters exposed for 13 weeks.
[cited from Chemicals Evaluation and Research Institute (CERI), Japan, Hazard assessment on Acetaldehyde 2007, http://www.cerij.or.jp/ceri_en/hazard_assessment_report/yugai_indx_en.htm]
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