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EC number: 277-552-6 | CAS number: 73612-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Strontium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
- EC Number:
- 277-552-6
- EC Name:
- Strontium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
- Cas Number:
- 73612-29-0
- Molecular formula:
- C18H14N2O6S.Sr
- IUPAC Name:
- strontium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate
- Test material form:
- solid: nanoform
- Details on test material:
- Test materials used in this dossier are all considered to fall under the definition of nano-materials according to the European Commission Recommendation 2011/696/EU as the synthesis and manufacturing of this pigment always yields particulate material with a fine particle size distribution.
Constituent 1
- Specific details on test material used for the study:
- - Physical state: powwder, red
- Analytical purity: the test substance has not been fully characterized analytically.
- Lot/batch No.: CS-485
- Stability under test conditions: has not been determined analytically.
- Storage condition of test material: room temperature
- Name of test material (as cited in study report): LITHOL RUBIN D 4569-SR-LACK, Substance number 91/3
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: DR . K . THOMAE GMBH, 7950 BIBERACH, BRD
- Age at study initiation: YOUNG ADULT ANIMALS
- Mean weight at study initiation: 150 - 300 g +- 20%
- Fasting period before study: AT LEAST 16 HOURS, WATER WAS AVAILABLE AD LIBITUM .
- Housing: SINGLE HOUSING.
- Diet (e.g. ad libitum): KLIBA-LABORDIAET 343, KLINGENTALMUEHLE AG 4303 KAISERAUGST, SWITZERLAND , AD LIBITUM .
- Water (e.g. ad libitum): TAP WATER AD LIBITUM PER DAY
- Acclimation period: AT LEAST 1 WEEK
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 H/12 H
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous tylose solution
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 22 g/100 mL, 0 .5% solution of Tylose CB 30.000 in Aqua Bidest.
- Justification for choice of vehicle: Aqueous formulation corresnponds to the physiological medium.
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- 2200 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Frequency of observations for signs and symptoms: recording of signs and symptoms several times on the day of administration, at least once ach workday for the individual animals.
- Frequency of general observations and mortality: check was made twice each workday and once on mortality: Saturdays, Sundays and on public holidays for general observations and for any dead or moribund animals.
- Frequency of weighing: individual body weights shortly before application (day 0), weekly thereafter and at the end of the study (before fasting period).
- Necropsy of survivors performed: Yes, necropsy at the last day of the observation period. Withdrawal of food at least 16 hours before euthanisation with CO2; then necropsy with gross pathology examination. Necropsy of all animals that died before as early as possible.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 200 mg/kg bw
- Mortality:
- No mortality observed
- Clinical signs:
- other: No abnormalities observed
- Gross pathology:
- No pathologic findings noted
- Other findings:
- Skin coloured red, discoloured feces (red) at day 1, noted in all animals
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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