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EC number: 201-187-3 | CAS number: 79-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl chloroformate
- EC Number:
- 201-187-3
- EC Name:
- Methyl chloroformate
- Cas Number:
- 79-22-1
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- methyl chloroformate
- Details on test material:
- - Name of test material (as cited in study report): Methylchlorformiat (methylchloroformate)
- Purity: about 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mura : SPRA (SPF 68 Han), MUS RATTUS, Brunnthal, Germany,
- Weight at study initiation: 185 +/- 15 g
- Fasting period before study:
- Housing: fully air-conditioned rooms
- Diet (ad libitum): ad libitum (except exposure); Herilan MRH of H . EGGERSMANN KG, RintelnNVeser
- Water (ad libitum): ad libitum (except exposure)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 55 +/- 5 %
- Photoperiod (hrs dark / hrs light): 12 / 12
:
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Exposure system: Whole-body inhalation system (Groups of 5 animals are placed in wire cages which are located in a glass-steel inhalation chamber, V= 200 I.) Generator system: Continuous infusion pump UNITA I(B . Braun); Glass evaporator with thermostat (BASF ). By means of a continuous infusion pump, constant amounts of the test substance (see Table) were supplied to an evaporator heated to 45°C . The vapors that were formed were mixed with a flow of fresh air and passed into the inhalation chamber.
By means of an exhaust air system, the pressure ratios in the inhalation system were adjusted in such a way that there was a pressure slightly below
the atmospheric pressure (negative pressure) . The inhalation mixture was offered to the animals for inhalation for 4 hours . - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Analytical concentration: 0.006 (group 4); 0.053 (group 3); 0.120 (group 2); 0.130 mg/l (group 1)
Nominal concentration: 0.06; 0.25; 0.49; 0.37 mg/l - No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing was before treatment, after 7 days, after 14 days. Observations were several times at the day of exposure and atleast once daily afterwards.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: daily - Statistics:
- The statistical evaluation of the study was carried out based on a probit analysis of D .J . Finney (Finney, D .J. : Probit Analysis 1971, pp 1-150 .
Published by the Syndics of the Cambridge University Press, Bentley House, 200 Euston Road, London N.W. 1) . The calculations were carried out in
the BASF Computer Center.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.06 mg/L air
- 95% CL:
- 0.04 - 0.074
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.053 mg/L air
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 0.07 mg/L air
- 95% CL:
- 0.032 - 0.095
- Mortality:
- 0.006 mg/l: males 0/10, females 0/10; 0.053 mg/l: males5/10, females 3/10; 0.120 mg/l: males 10/10, females 10/10;
0.130 mg/l: males 10/10, females 7/10
The fatally intoxicated animals died during the test up to 11 days afterward. - Clinical signs:
- other: (Group 1-3): Dyspnea ; gasping breathing with whooping sounds in some cases; blistering in front of the noses ; reddish discharge from the eyes and noses ; incrustations around the eyes and noses occurring later ; ruffled and sticky fur with yellow discol
- Body weight:
- As regards the relative body weight gain, the males of Group 3 and the females of Groups 1 and 3 were considerably impaired after 7 days, but there
was an adjustment to the control groups after 14 days . The males and females of Group 4 did not reveal any substantial differences from the controlanimals . - Gross pathology:
- Animals that died:
Heart: acute dilatation ; acute passive hyperemia
Lungs: infarctoid congestion, wet and sarcoid in some cases; edematized; marginal emphysema ; hydrothorax in several cases
Liver: slight and sometimes only focal peripheral hepatocellular fatty degeneration sporadically
Sacrificed animals :
Organs: no abnormalities detected
Applicant's summary and conclusion
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