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EC number: 208-778-5 | CAS number: 541-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl chloroformate
- EC Number:
- 208-778-5
- EC Name:
- Ethyl chloroformate
- Cas Number:
- 541-41-3
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- ethyl chlorocarbonate
- Details on test material:
- - Name of test material (as cited in study report): Ethylchloroformiat
- Analytical purity: not reported
- internal Test substance No. 82/21.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler (Offenbach, Germany).
- Age at study initiation:
- Weight at study initiation: approx. 2.9 kg.
- Housing: 1 rabbit per cage; stainless steel with wire mesh walk floor; walking area 40 cm x 51 cm.
- Diet (e.g. ad libitum): standard diet Ovator Solikanin 4 mm, approx. 130g per animal and day.
- Water (e.g. ad libitum): 250 ml per animal and day of demineralized water (Monday-Friday) or tap water (weekends).
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26°C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12/12 hrs
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml of the neat test substance;
- Duration of treatment / exposure:
- 1 and 4 hours
- Observation period:
- 7 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: several 3cm x 3cm treatment sites (left and right front and back flanks)
- Type of wrap if used: the tape was fixed with a permeable bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the skin was rinsed and dried
- Time after start of exposure: after 1 , 4 h, respectively
SCORING SYSTEM: similar to the table contained in OECD TG 404.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 2.6
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 1 hour contact
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 1.9
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 1 hour contact
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 2.8
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 hour contact
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 -72 h
- Score:
- 2.2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 hour contact
- Irritant / corrosive response data:
- superfacial necrosis was observe after 1 and afte 4 h semi occlusive exposure to ethychloroformate. The absence of full thickness necrosis was verified by a pathologist. Therefore, EhCF is extremely irritating but not corrosive in this study.
- Other effects:
- Pathology: after sacrifice the animals were subjected to gross pathology. If there were signs of necroses, these were confirmed by gross pathologicalexamination after incision of the skin.
Any other information on results incl. tables
(1) Skin reactions (means of 6 animals) following the 1-hr
occlusive contact period were as follows:
--------------------------------------------
Examination Skin reaction
ER ED Remarks
--------------------------------------------
1 hour 2.17 2.83 N
24 hours 2.17 2.5 N
48 hours 2.67 1.67 N
72 hours 2.67 1.83 N
7 days 3.67 1.5 N
--------------------------------------------
ER=erythema, ED=edema, N=necrosis
Erythema and edema extended beyond the exposure area in all animals at all readings.
Superficial necroses were seen in 1/6 animals at 48 h post application, and in 5/6 animals at the end of the observation period, 7 days after application.
(2) Skin reactions (means of 6 animals) following the 4-hr
occlusive contact period:
--------------------------------------------
Examination Skin reaction
ER ED Remarks
--------------------------------------------
1 hour 2.50 3.33 N
24 hours 2.50 2.50 N
48 hours 2.83 2.33 N
72 hours 3.17 1.83 N
7 days 4.0 1.50 N
--------------------------------------------
ER=erythema, ED=edema, N=necrosis
Erythema and edema extended beyond the exposure area in all animals at all readings.
Superficial necroses were seen in one animals (1/6) as early as 1 h after patch removal and in all animals (6/6) at the end of the observation period, 7 days after treatment.
Applicant's summary and conclusion
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