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Diss Factsheets
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EC number: 208-778-5 | CAS number: 541-41-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Due to lower dokumentation requirements in times before GLP the study is reliable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ethyl chloroformate
- EC Number:
- 208-778-5
- EC Name:
- Ethyl chloroformate
- Cas Number:
- 541-41-3
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- ethyl chlorocarbonate
- Details on test material:
- - Name of test material (as cited in study report): Aethylchlorkohlensäureester (ethy carbonochloric acid ester)
- Substance type:
- Physical state: liquid
- Analytical purity: ca. 95 %
- internalTest substance No. XIX/351.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: 216,9 +/- 27.7 (males); 166,8 +/-15,3 (females
- Fasting period before study: no data (probably: yes)
- Housing: no data (probably: grousp of 5)
- Diet (e.g. ad libitum): no data (probably: ad libitum)
- Water (e.g. ad libitum): no data (probably: ad libitum)
- Acclimation period:no data
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Vehicle aqueous solution with 0.1 -1 % traganth gum
- Concentration in vehicle: 1 %
MAXIMUM DOSE VOLUME APPLIED: ca. 10 ml - Doses:
- 80, 100, 125, 160, 200,250, 320, 400 µl/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were several times the day of application and at least daily thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 205 mg/kg bw
- Remarks on result:
- other: desity 1,14 g/cm3
- Mortality:
- 400 µl/kg: 10/10 male and 10/10 female (within the first 24 h)
320 µl/kg: 10/10 male and 10/10 female (with the exeption of one male all within the first 24 h)
250 µl/kg: 5/10 male and 10/10 female (all death occurred within the first 48 h)
200 µl/kg: 5/10 male and 8/10 female
160 µl/kg: 2/10 male and 1/10 female
125 µl/kg: 0/10 male and 6/10 female
100 µl/kg: 0/10 male and 6/10 female
80 µl/kg: 0/10 male and 2/10 female - Clinical signs:
- Dyspnea; apathy; staggering; abdominal and lateral position; sometimes twitching
- Body weight:
- not determined at the end of the study
- Gross pathology:
- Animals founfd dead: Dark-red discoloration of the gastric mucosa; reddish intestinal contents; serous membranes rich in liquids. 2 x lung edema
Sacrificed animals: nothing abnormal
Any other information on results incl. tables
LD 50 was estimated to be 180 µL/kg. this is equivalent to 205 mg/kg bw based on a density of 1.14 g/cm³ at 20°C
Signs of toxicity: dyspnea; apathy; staggering; abdominal and lateral position; sometimes twitching.
Necropsy findings: dark-red discoloration of the gastric mucosa; reddish intestinal contents; serous membranes rich in liquids.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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