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EC number: 203-328-4 | CAS number: 105-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test conducted according to OECD guideline 403
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Dibutyl maleate
- EC Number:
- 203-328-4
- EC Name:
- Dibutyl maleate
- Cas Number:
- 105-76-0
- Molecular formula:
- C12H20O4
- IUPAC Name:
- dibutyl but-2-enedioate
- Details on test material:
- Dibutylmaleinat, dibutyl maleate, K. Nr.: 215 7135
Supplier: Chemie Linz GmbH
Impurities: unknown
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source - Commercial supplier Sprague-Dawley (Him:OFA)
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- The mass mediated diameter of the test substance aerosol was 2.7 µm. 80% of the mass was in the fraction with a diameter of less than 5 µm. Upon analysis of the test material, it was determined that the actual mean concentration of dibutyl maleate was 4690 mg/m3 which is 95% of the target concentration.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- By spectrophotometric detection of phenolred at 564 nm and verified by HPLC analysis.
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 5000 mg/m3 in aerosol
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- not specified
- Statistics:
- no data
Results and discussion
- Preliminary study:
- No adverse effects.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 000 mg/m³ air
- Remarks on result:
- other: no data on confidence limits
- Mortality:
- All animals survived.
- Clinical signs:
- other: No related observations were noted during and after the treatment period.
- Body weight:
- No relevant changes as compared to untreated animals.
- Gross pathology:
- Changes were observed on the lungs of four males and three females and recorded as "small hemorrhages."
- Other findings:
- No differences were oberved between male and female rats.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 was determined to be greater than 5000 mg/m3 (in aerosol)
- Executive summary:
The potential toxic effects of dibutyl maleate were assessed in an acute inhalation test according to the OECD guideline 403. Animal were exposed to the test substance via nose-only for 4 hour at a concentration of 5000 mg/m3. All animals survived the test. No behavioral observations were made during and after the treatment period. At necropsy during the macroscopic examination, changes identified as "small hemorrhages" were noted on the lungs of four males and three females. The LC50 was determined to be greater than 5000 mg/m3 (in aerosol).
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