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Diss Factsheets
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EC number: 203-509-8 | CAS number: 107-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Uptake, Accumulation, and Biomarkers of PM2.5-Associated Organophosphate Flame Retardants in C57BL/6 Mice after Chronic Exposure at Real Environmental Concentrations
- Author:
- Chen M
- Bibliographic source:
- Environ. Sci. Technol. 2020, 54, 9519−9528
Materials and methods
- Principles of method if other than guideline:
- no guideline followed
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- other: intratracheal
- Details on exposure:
- 20 μL of an OPFR standard solution (mixture of 6 different flame retardants, including tributyl phosphate) or 20 μL 0.9% saline was injected through the mouth into the trachea. The OPFR exposure concentrations are calculated based on the respiratory volume of an adult mouse (30 mL·min−1). Instillation was performed once every three days for 72 days.
Results and discussion
Results of examinations
- Details on results:
- The mice were randomly divided into four groups, each with eight mice: a control group (C-group), a low OPFR dosage group (L-group, 0.088 μg·kg−1·day−1) whose dosage corresponds approximately to the OPFR concentration observed in PM2.5 samples collected in Guangzhou during winter, a medium dosage group (M-group, 0.88 μg·kg−1·day−1), and a high dosage group (H-group, 8.8 μg·kg−1·day−1). Intratracheal instillation of mice was performed as described previously. Briefly, 20 μL of an OPFR standard solution (mixture of 6 different flame retardants, including tributyl phosphate) or 20 μL 0.9% saline was injected through the mouth into the trachea. The OPFR exposure concentrations are calculated based on the respiratory volume of an adult mouse (30 mL·min−1). Instillation was performed once every three days for 72 days. After 72 days of exposure mice were sacrificed after the final exposure and all samples were stored at −80 °C. The sum of organophosphate flame retardants (OPFR) concentrations in tissues from mice in the medium dosage group decreased in the order of intestine > heart > stomach > testis > kidney > spleen > brain > liver > lung > muscle. Of the OPFRs detected in all three exposure groups, chlorinated alkyl OPFRs were most heavily accumulated in mice. We found a significant positive correlation between the bioaccumulation ratio and octanol−air partition coefficient (KOA) in mice tissues for low log KOW OPFR congeners (log KOW ≤ 4, p < 0.05). Three urinary metabolites (di-p-cresyl phosphate: DCrP, diphenyl phosphate: DPhP, dibutyl phosphate: DnBP) were detected from the high dosage group.
This study is of low relevance for the assessment of di- and tributyl phosphate due to test item being a OPFR mixture, the intratracheal route of exposure, the explorative nature and test system.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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