Registration Dossier
Registration Dossier
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EC number: 203-509-8 | CAS number: 107-66-4
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity, other
- Remarks:
- oral and dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: method and results insufficient documented
Data source
Reference
- Reference Type:
- publication
- Title:
- Organophosphorousester-induced delayed neurotoxicity
- Author:
- Abou-Donia MB
- Year:
- 1 981
- Bibliographic source:
- Ann Rev Pharmacol Toxicol 21, 511-548 (1981)
Materials and methods
- Principles of method if other than guideline:
- Examination of delayed neurotoxicity in hens after subchronic dermal (or oral) and application of dibutyl hydrogen phosphate.
Test material
- Reference substance name:
- Dibutyl hydrogen phosphate
- EC Number:
- 203-509-8
- EC Name:
- Dibutyl hydrogen phosphate
- Cas Number:
- 107-66-4
- Molecular formula:
- C8H19O4P
- IUPAC Name:
- dibutyl hydrogen phosphate
Constituent 1
Test animals
- Species:
- hen
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral and dermal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw/day
Basis:
nominal conc.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- other: delayed neurotoxicity
- Effect level:
- 100 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Remarks on result:
- other:
Any other information on results incl. tables
Delayed neurotoxic effects were observed in hens after oral or dermal administration of 100 mg/kg bw/day dibutyl hydrogen phosphate for 90 days.
Applicant's summary and conclusion
- Executive summary:
Examination of delayed neurotoxicity in hens after subchronic dermal (or oral) and application of dibutyl hydrogen phosphate.
Delayed neurotoxic effects were observed in hens after oral or dermal administration of 100 mg/kg bw/day dibutyl hydrogen phosphate for 90 days.
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