Benzophenone-3,3':4,4'-tetracarboxylic dianhydride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Precedes establishment of guidelines and GLP. Documentation is limited.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)

GLP compliance:

not specified

Test type:

fixed concentration procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Benzophenone-3,3':4,4'-tetracarboxylic dianhydride

EC Number:

219-348-1

EC Name:

Benzophenone-3,3':4,4'-tetracarboxylic dianhydride

Cas Number:

2421-28-5

Molecular formula:

C17H6O7

IUPAC Name:

5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dione

Constituent 2

Reference substance name:

291-348-1

IUPAC Name:

291-348-1

Test material form:

solid: crystalline

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

clean air

Details on inhalation exposure:

stainless steel inhalation chamber, 1530 L. Total air flow through the system was 50 liters per minute. The actual chamber concentration was not determined during the exposure. The mean theoretical concentration was calulated from the air flow and net loss of material was 4.72 mg per liter.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

6 h

Control animals:

no

Details on study design:

During the exposure, all animals were continuously observed for mortality and toxic effects. Following exposures, the animals were group-housed in metal cages suspended above droppings. Food and water were freely available during the pre-exposure period of adjustment to the laboratory environment and the post-exposure period. During the 14 day post-exposure period, the animals were observed daily for possible latent effects. Necropsies were performed following the sacrifice of the test animals at the termination of the study.

Statistics:

no data

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LC0

Effect level:

4.44 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

6 h

Remarks on result:

other: No deaths

Mortality:

no deaths

Clinical signs:

other: Slight evidence of lung damage such as foci of consolidation were noted at time of necropsy. As these were also noted in control animals, they were not considered to be related to the test material.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information

Conclusions:

1,3-Isobenzofurandione, 5,5'-carbonylbis- (BTDA) was tested for acute inhalation lethality in rats in a protocol similar to OECD 433. No deaths or adverse effects occurred at concentrations of 4.44 mg/L.