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EC number: 215-542-5 | CAS number: 1330-61-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental toxicokinetic study was not available on isodecyl acrylate.
Based on the chemical and physical data, a low absorption of isodecyl acrylate is expected after oral route, dermal route or inhalation.
Key value for chemical safety assessment
Additional information
Experimental toxicokinetic study was not available on isodecyl acrylate.
Chemical and physical properties of isodecyl acrylate :
- Molecular weight : 212, 33 g/mol
-Vapour pressure: 3,61 Pa (20°C)
-Water solubility: 1,34 mg/L
-Log Kow: 5.55
Information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, according to the REACH guidance document R7.C (2012).
ABSORPTION
Based on the physicochemical characteristics of isodecyl acrylate, a log Kow higher than 5 and a low water solubility, a low oral absorption is expected. This assumption of a low oral absorption is confirmed by the data acute oral toxicity (LD50 = 9486 mg/kg bw in rats).
Dermal absorption of isodecyl acrylate is expected to be slowed due to binding to skin of the acrylate group and the low solubility water. This is supported by the low toxicity observed in acute dermal testing (LD50 > 3150 mg/kg bw). However, isodecyl acrylate is a moderate skin sensitizer based on the LLNA. Finally, a dermal absorption of isodecyl acrylate is expected to be low.
According to the value of the vapour pressure (3,61 Pa at 20°C), isodecyl acrylate is considered to be slightly volatile. In the data acute toxicity, no death and no clinical signs were observed at the dose of 0,333 mg/L (maximum attainable concentration). No absorption by inhalation of isodecyl acrylate is expected at the maximum attainable concentration due to the low values of vapour pressure and water solubility.
DISTRIBUTION/ METABOLISM/ EXCRETION
As a small molecule a wide distribution of isodecyl acrylate is expected.
No specific information was found on metabolism of isodecyl acrylate.
However, according to the hydrolysis tests performed on isodecyl acrylate, the substance is stable at the pH 4 and 7. Therefore no hydrolysis is expected in the rodent (stomach pH between 3 and 5).
But at the pH 1 and 9, isodecyl acrylate is not stable. Evidence from other types of acrylates suggests that hydrolysis of the ester bond is likely to occur, producing acrylic acid and the corresponding alcohol, which are subsequently metabolised through normal metabolic routes.
The major routes of excretion for both substances from the systemic circulation are the urine (due to the low molecular weight) and the exhaled air (of the hydrolysis products).
Bibliographic sources
De Bethizy et al.(1987). Fund. Appl. Tox. 8: 549-561
Deisinger PJ, Boatman RJ and Guest D (1994.Xenobiotica 24, 429-440
Frederick et al. (1992). Toxicol.Appl. Pharm. 114: 246-260
Frederick et al. (1994). Toxicol. Lett. 70: 49 -56
Ghanayem et al. (1987). Fundam. Appl. Toxicol. 9: 389-397
Linhart et al.(1994). Xenobiotica 24: 1043-1052
McCarthy TJ and Witz G (1997). Toxicology 116, 153-158
Roos K., Bachelorthesis, 2014
Silver and Murphy (1981). Toxicol.Appl. Pharmacol. 57: 208-219
Vodicka et al. (1990). Toxicology 65: 209-22
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