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EC number: 230-745-9 | CAS number: 7300-34-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The substance is not readily biodegradable, according to OECD criteria.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of DODA (CAS 7300 -34 -7) (Q)SAR results were used for aerobic biodegradability in water.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on aerobic biodegradability in water are not provided.
Assessment:
No experimental data are available for 3,3'-[Butane-1,4 -diylbis(oxy)]bispropanamine (DODA; CAS 7300-34-7). Therefore, in order to assess the biodegradation potential of DODA (CAS 7300-34-7), a read across to the structurally similar substance 3,3'-oxybis(ethyleneoxy)bis(propylamine) (CAS 4246-51-9) was performed. Experimental data are available from an enhanced ready biodegradability test according to OECD 301B, conducted with non-adapted, domestic activated sludge as inoculum (BASF SE, 2011). Under test conditions no biodegradation was observed (-5% CO2 evolution after 60 days, BASF SE, rep. no.: 22G0401/11G051, 2011). Therefore, as a worst-case consideration the structurally similar substance is evaluated to be not readily biodegradable in this enhanced biodegradability test according to OECD 301B.
In addition to the read-across approach, the ready biodegradability of DODA was assessed using two QSAR models. The substance was within the applicability domains of the used models.
- BIOWIN v4.10 (EPI Suite v4.11): readily biodegradable
- CATALOGIC Kinetic OECD 301C v.11.15: 12% in 28 d, not readily biodegradable
Based on the available experimental data from the read-across approach to the structurally similar substance (CAS 4246-51-9) along with available estimated data for the substance itself, it can be concluded, that DODA (CAS 7300-34-7) is not readily biodegradable, according to OECD criteria.
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