Registration Dossier
Registration Dossier
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EC number: 233-238-0 | CAS number: 10099-59-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A key study (Hefner, 2014a) is available that investigated lanthanum toxicity to juvenile rainbow trout (Oncorhynchus mykiss). This key study was assigned a Klimisch 1 score. The 96-h LC50 reported in this study is 1.01 mg La(NO3)3/L corresponding to 0.42 mg La/L, meaning that lanthanum trinitrate is toxic to fish. This 96-h LC50 is considered as the key value for this endpoint and will be taken forward for classification purposes.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.42 mg/L
Additional information
There are three studies included in this dossier on acute lanthanum toxicity to fish (Bazin, 1996; Peterson et al., 1974; Hefner, 2014a).
The key study was the study of Hefner (2014a). In this study, juvenile rainbow trout (Oncorhynchus mykiss) were exposed to lanthanum (added as La(NO3)3) for 96 h in a semi-static test. Dissolved lanthanum concentrations were monitored in fresh as well as old test media at the start and end of each renewal period, respectively. A 96-h LC50 of 1.01 mg La(NO3)3/L, corresponding to 0.42 mg La/L was obtained. This value should be considered as a key value and will be taken forward for classification purposes. Lanthanum trinitrate can be considered as toxic to fish.
The study of Peterson et al. (1974) reported a 96-h LC50 value of 0.47 mg La/L for Coho salmon (Oncorhynchus kisutch) from a test in which LaCl3 was used to add lanthanum to the test media. Lanthanum concentrations were however not measured, hence the results of this study may have been underestimated. The study was not considered reliable but can be considered as a supporting study due to consistent results with the key study.
The study of Bazin (1996) exposed juvenile rainbow trout (Oncorhynchus mykiss) to lanthanum (added as La(NO3)3) for 96 h and concluded that the LC50 was higher than 100 mg/L (as La(NO3)3). However, since the lanthanum concentration in the water column had decreased below 1 mg La/L after 24 h, toxicity may have been substantially underestimated in this test, which is also confirmed by the results of the other two available studies (see above). Therefore, the results of this study were disregarded.
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