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EC number: 689-986-7 | CAS number: 1742-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 July 2013 to 27 March 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Fully GLP compliant and in accordance with current test guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-oxo-1,2-dihydropyridin-1-yl acetate
- EC Number:
- 689-986-7
- Cas Number:
- 1742-79-6
- Molecular formula:
- C7H7NO3
- IUPAC Name:
- 2-oxo-1,2-dihydropyridin-1-yl acetate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name: Oxypyrionacetate
CAS number: 1742-79-6
Batch number: 14058400
Molecular weight: 153 g/mol
Storage details: stored refrigerated (2 °C to 8 °C) in the dark
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Reference substance: diethylene glycol
Carbon content: expressed as a percentage by weight is 45.27%.
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- A sample of activated sludge was collected from one of the return lines at Burley Menston sewage treatment works (West Yorkshire, UK), which has a predominantly domestic waste-water catchment. The sample was transported to Smithers Viscient in a closed container, but with an adequate headspace, to prevent the sample becoming anaerobic.
On arrival, the sample was washed by allowing the solids to settle, removing the supernatant and replacing it with an equal volume of mineral media. The washed sample was aerated by means of a compressed air supply.
The suspended solids concentration of the activated sludge was determined by filtering a subsample (25 mL) through a pre-dried and pre-weighed glass microfibre filter (Whatman GF/C). The filter and retained solids were then dried in an oven and re-weighed. The weight of the sludge solids was determined from the difference in the weights before and after drying.
The activated sludge used in this study was not deliberately acclimatised or adapted to oxypyrion acetate before exposure under test conditions. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 50 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
-Composition of medium: The mineral medium used in this study (after dilution of the mineral medium concentrate) contained 10 mL/L solution of Potassium dihydrogen phosphate (8.50 g), Dipotassium hydrogen phosphate (21.75 g), Disodium hydrogen phosphate dihydrate (33.40 g) and Ammonium chloride (0.50 g), 1 mL/L of each of Calcium chloride dihydrate (36.40 g), Magnesium sulphate heptahydrate (22.50 g), Ferric chloride hexahydrate (0.25 g) and Hydrochloric acid (1 drop).
- Test temperature: 22 ± 2°C
- pH: 7.48 to 7.51 at Day 0 and 7.40 to 7.55 at Day 28
- pH adjusted: no
- CEC (meq/100 g): Not applicable
- Aeration of dilution water: was delivered from a cylinder of CO2-free air (Air Products)
- Suspended solids concentration: Not reported
- Continuous darkness: yes
TEST SYSTEM
- Method used to create aerobic conditions: aerated by means of a compressed air supply
- Details of trap for CO2 and volatile organics if used: . Each vessel was sealed, connected to a series of three traps containing aqueous barium hydroxide (nominally 0.0125M)
SAMPLING
- Sampling frequency: 2, 5, 7, 9, 12, 14, 19, 23, 28 and 29 Day
- Sampling method: trap bottle nearest to the test vessel was removed for sampling. The initial barium hydroxide stock concentration and the residual concentrations in detached trap bottles were determined by titration against hydrochloric acid (nominally 0.05M) using 0.5% ethanolic phenolphthalein indicator solution.
- Sterility check if applicable: Not applicable
- Sample storage before analysis: Not applicable
CONTROL AND BLANK SYSTEM
- Inoculum blank: inoculated mineral salts medium
- Abiotic sterile control: Mineral salts medium inoculated with sterilised inoculum and test substance
- Toxicity control: inoculated mineral salts medium, test substance and diethylene glycol
- Other: Dose control - Un-inoculated mineral salts medium and test substance
Reference substance
- Reference substance:
- diethylene glycol
Results and discussion
- Preliminary study:
- Not applicable
- Test performance:
- pH values in all vessels ranged from 6,52 to 8,08. DO measurements in all vessels ranged from 6,89 mg/l to 8,68 mg/l indicating aerobic conditions. The pH and DO values were within the limits specified in the protocol with one deviation: at Day 21 the abiotic control pH (8.08) was slightly higher than the limit of 8.0 and was not adjusted in error. The pH of the abiotic control vessel was within the limits at the following two sampling occasions. This is not considered to have had an impact on the integrity of the study.
% Degradation
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 99
- Sampling time:
- 29 d
- Remarks on result:
- other: inherently biodegradable
- Remarks:
- Not readily biiodegradable
- Details on results:
- To be considered inherently biodegradable, a test substance must achieve 20% biodegradation by the end of the test. After 2 days, 22% mean biodegradation was observed; by the end of the test, 99% mean biodegradation was observed and oxypyrion acetate can therefore be considered to be inherently biodegradable.
Assessment of biodegradation in the toxicity control was calculated for the diethylene glycol fraction only. The biodegradation of the reference substance in the presence of oxypyrion acetate was 100% at 14 days, suggesting that oxypyrion acetate did not have an inhibitory effect on the sludge microorganisms under the test conditions. Results from study 3200294 show that oxypyrion acetate degrades rapidly in water to oxypyrion and (theoretically) acetic acid.
BOD5 / COD results
- Results with reference substance:
- The mean percentage biodegradation for vessels containing the reference substance alone was 100% at Day 14. The validity criterion of 70% removal at 14 days was therefore met.
Any other information on results incl. tables
Biodegradation as a Percentage of Initial Carbon Concentration
|
% Biodegradation |
|||||
Day 2 |
Day 7 |
Day 14 |
Day 21 |
Day 27 |
Day 28 |
|
Reference substance replicate 1 |
1 |
100 |
100 |
100 |
100 |
100 |
Reference substance replicate 2 |
5 |
100 |
100 |
100 |
100 |
100 |
Mean |
3 |
100 |
100 |
100 |
100 |
100 |
Test substance replicate 1 |
21 |
78 |
100 |
100 |
100 |
100 |
Test substance replicate 2 |
23 |
88 |
100 |
100 |
100 |
99 |
Mean |
22 |
83 |
100 |
100 |
100 |
99 |
Toxicity control |
17 |
24 |
100 |
101 |
100 |
101 |
Abiotic control |
1 |
38 |
96 |
98 |
97 |
97 |
Note: Numbers are rounded for presentation. Consequently, the displayed mean may not be the calculated mean of the rounded individual values shown. All values are corrected for blank control. Negative numbers are reported as zero. Toxicity Control results are expressed in terms of concentration of reference substance alone. |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- The validity criterion was satisfied and the results of this study are therefore considered to be valid.
Biodegradation of oxypyrion acetate was 22% after 2 days and 99% at 28 days. The level of biodegradation observed satisfies the requirements for inherent biodegradability and oxypyrion acetate can therefore be classified as inherently biodegradable. - Executive summary:
The inherent and primary biodegradability of oxypyrion acetate was assessed by measurement of dissolved organic carbon elimination under standard conditions. The study was carried out in accordance with OECD Guideline 302B, Zahn Wellens/EMPA test (Adopted July 1992).
The test substance, oxypyrion acetate (CAS 1742-79-6), was added to the test system in an aqueous solution to give a test substance concentration equivalent to 50 mg organic carbon/l. The procedure and the activity of the inoculum were checked by measuring the dissolved organic carbon (DOC) eliminated from vessels containing a reference substance, diethylene glycol. Blank control, abiotic control and toxicity control groups were also included.
The medium was inoculated with microorganisms derived from a sample of activated sludge not previously intentionally exposed to the test substance. Test vessels were incubated in darkness at 20 – 24 °C for 28 days and their contents continuously stirred and aerated. At intervals, samples were removed and subjected to DOC analysis (and HPLC-MS analysis, where appropriate).
Mean % biodegradation of oxypyrion acetate was 22% after 2 days, reaching 99% at 28 days. The level of biodegradation observed satisfies the requirements for inherent biodegradability and oxypyrion acetate can therefore be classified as inherently biodegradable. Results from study 3200294 show oxypyrion acetate degrades rapidly in water to oxypyrion and (theoretically) acetic acid.
All validity criteria were satisfied and the results of this study are therefore considered to be valid.
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