2-chloro-4,6-dimethoxy-1,3,5-triazine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28 may to 16 July 1997

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: well documented guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-chloro-4,6-dimethoxy-1,3,5-triazine

EC Number:

221-541-0

EC Name:

2-chloro-4,6-dimethoxy-1,3,5-triazine

Cas Number:

3140-73-6

Molecular formula:

C5H6ClN3O2

IUPAC Name:

2-chloro-4,6-dimethoxy-1,3,5-triazine

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

arachis oil

Doses:

Range finding:
5000 mg/kg, 2000 mg/kg, 1000 mg/kg, 500 mg/kg, 200 mg/kg,
Main study
707 mg/kg, 1000 mg/kg, 1400 mg/kg,

No. of animals per sex per dose:

Main study 5 per sex

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

870 mg/kg bw

Based on:

test mat.

95% CL:

> 812 - < 933

Any other information on results incl. tables

Dose level mg/kg	Sex	Number of Animals treated	Deaths During Day of Dosing (hour)				Deaths During Day of Dosing (days)								Deaths	%
			1/2	1	2	4	1	2	3	4	5	6	7	8-14
707	Male female	5 5	0 0	0 0	0 0	0 0	0 0	0 0	0 0	0 0	0 0	0 0	0 0	0 0	0 0	0 0
1000	Male female	5 5	0 0	0 0	0 0	0 0	4 5	0 -	0 -	0 -	0 -	0 -	0 -	0 -	0 -	0 -
1414	Male female	5 5	0 0	2 2	0 1	0 1	3 1	- -	- -	- -	- -	- -	- -	- -	- -	- -

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

2-Chloro-4,6-dimethoxy-1,3,5-Triazin has a LD50 of 870 mg/kg when administred orally. Hence it has to be classified as harmful.

Executive summary:

A study with Spague-Dawley rats was performed according to OECD 401. After a range finding study the doses 707 mg/kg 1000 mg/kg and 1414 mg/kg were given by gavage. Deaths and clinical signs were observed.

The acute oral median lethal dose LD50 and 95% confidence limit of the test material were calculated by the method of Thompson W R to be: 870 (812 - 913) mg/kg bodyweight.