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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16/05/1997 to 30/05/1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study with sufficient documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
EC Number:
221-541-0
EC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine
Cas Number:
3140-73-6
Molecular formula:
C5H6ClN3O2
IUPAC Name:
2-chloro-4,6-dimethoxy-1,3,5-triazine

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
0.5 g + 0.5 ml Water
Duration of treatment / exposure:
4 h exposure
Observation period:
24h / 48h / 72h after removing of substance
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 1 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 1 h
Score:
ca. 3
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 48 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 h
Score:
ca. 2
Max. score:
2
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h
Score:
ca. 2.5
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 48 h
Score:
ca. 2
Max. score:
3
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 72 h
Score:
ca. 2
Max. score:
3
Reversibility:
fully reversible

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Accoring to the test result 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine is moderate irritant to the skin.
Executive summary:

Accoring to the test result 2-Chloro-4,6-Dimethoxy-1,3,5-Triazine is moderate irritant to the skin.

6 from 6 rabbits had moderate skin irritation that where fully reversible.