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EC number: 949-986-2 | CAS number: 49720-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- melting point/freezing point
- Remarks:
- melting point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- GLP compliance:
- not specified
- Type of method:
- thermal analysis
- Key result
- Decomposition:
- yes
- Decomp. temp.:
- ca. 125 - ca. 400 °C
- Remarks on result:
- other: no determation of melting point possible. The substance decomposes.
- Conclusions:
- L-arginine phosphate monohydrate has been characterized by thermal analysis as advised in OECD Guideline 102, point 8, Table 1, aiming to determine its melting point and facilitate calculation of vapour pressure. The presented results clearly demonstrate that L-arginine phosphate monohydrate decomposes in three distinct stages between approximately 125 °C – 400 °C (see Figure 1 and Figure 2 in the report) rather than display specific melting points. Hence, a melting point cannot be determined due to decomposition.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- yes
- Remarks:
- expert judgement and read-across from melting point property
- GLP compliance:
- not specified
- Type of method:
- other: thermal analyses
Test material
- Reference substance name:
- L-arginine phosphate
- EC Number:
- 949-986-2
- Cas Number:
- 49720-39-0
- Molecular formula:
- C6H19N4O7P
- IUPAC Name:
- L-arginine phosphate
- Test material form:
- solid: crystalline
- Remarks:
- particulate/powder
Constituent 1
Results and discussion
Vapour pressure
- Key result
- Temp.:
- ca. 25 °C
- Vapour pressure:
- <= 0 mm Hg
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- decomposition at 125-400 Celcius. Expected vapour pressure.
Transition / decomposition
- Key result
- Transition / decomposition:
- yes
- Remarks:
- decomposition at 125-400 Celcius
Applicant's summary and conclusion
- Conclusions:
- The high temperature and energy required for decomposition of the compound and the lack of a mass loss prior to this decomposition suggests that L-arginine phosphate monohydrate displays similar properties as the closely related compounds L-arginine (CAS No. 74-79-3) and L-arginine·HCl (CAS No. 1119-34-2), reported as ≤ 0 mm Hg at 25 °C. The vapour pressure for L-arginine phosphate monohydrate can therefore be expected to be ≤ 0 mm Hg at 25°C.
- Executive summary:
L-arginine phosphate monohydrate has been characterized by thermal analysis as advised in OECD Guideline 102, point 8, Table 1, aiming to determine its melting point and facilitate calculation of vapour pressure. The presented results clearly demonstrate that L-arginine phosphate monohydrate decomposes in three distinct stages between approximately 125 °C – 400 °C (see Figure 1 and Figure 2) rather than display specific melting points. Hence, a melting point cannot be determined due to decomposition.
Decomposition also means the crystalline compound has no vapour pressure that can be determined as mentioned in Guideline 104, point 3. The high temperature and energy required for decomposition of the compound and the lack of a mass loss prior to this decomposition suggests that L-arginine phosphate monohydrate displays similar properties as the closely related compounds L-arginine (CAS No. 74-79-3) and L-arginine·HCl (CAS No. 1119-34-2), reported as ≤ 0 mm Hg at 25 °C. The vapour pressure for L-arginine phosphate monohydrate can therefore be expected to be ≤ 0 mm Hg at 25°C.
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