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EC number: 479-940-2 | CAS number: 613246-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2004-09-27 to 2005-03-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study, however no hydrolysis guideline was followed
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105 guideline „Water Solubility" , adopted July 27th 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU-Guideline A. 6 „Water Solubility" published July 31st 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD: "Partitio n coefficient (n-Octanol/water): slow stirring method"; draft guideline, published Nov. 2003
- Deviations:
- no
- Principles of method if other than guideline:
- In the course of the water solubility study, the hydrolysis behaviour of the test substance was recorded.
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- After time intervals ranging from 1 hour to 72 hours, samples of the water in the flasks were analysed.
Furthermore, hydrolysis was investigated in a time period from 0 to 24 hours after spiking under oxygen-free conditions. - Buffers:
- No buffers were used.
- Details on test conditions:
- Sample preparation:
Nine round bottom flasks with 250 mL nominal volume were filled with 200 mL water each, degassed with vacuum until boiled for 2 minutes and bubbled with argon. 10 mL water of the first flask were taken and analysed as given above as matrix blank, and to the other eight flasks, 20 µL spiking solution of test item in acetone (concentration 2602 mg/L) were added, giving a nominal concentration of 0.26 mg/L in each flask. - Duration:
- 72 h
- Initial conc. measured:
- 0.26 mg/L
- Positive controls:
- no
- Negative controls:
- yes
- Remarks:
- blank control
- Test performance:
- Even after one hour, no aldehyde could be detected and no carbonic acid was produced. Therefore, the experiment was performed a second time, with sampling after 1 minute and after 30 minutes.
- Transformation products:
- yes
- Details on hydrolysis and appearance of transformation product(s):
- Carbon acid was not produced because of the strict absence of oxygen. An explanation for the decrease of test substance concentration is hydrolysis or adsorption, but hydrolysis is more probable because of the increasing background peaks, which implement the formation of decomposition products.
- Details on results:
- It could be shown that the concentration of the test substance fell below the LOQ within the first hours after spiking. The test item reacts with oxygen-free water in approx. 60 minutes to products other than the carbon acid, the latter being a product of the reaction with oxygen. The appearance of new peaks in the GC-chromotograms indicates the appearance of degradation (hydrolysation) products.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- In the course of a study, in which the water solubility of the test substance was determined the hydrolysis of the test substance was clearly observed. The test item reacts with oxygen-free water in approx. 60 minutes to products other than the carbon acid, the latter being a product of the reaction with oxygen.
- Executive summary:
In the course of a study, in which the water solubility of the test substance was determined according to OECD guideline no. 105 and EU method A.16 the hydrolysis of the test substance was clearly observed. The test item reacts with oxygen-free water in approx. 60 minutes to products other than the carbon acid, the latter being a product of the reaction with oxygen. The appearance of new peaks in the GC-chromotograms indicates the appearance of degradation products due to hydrolysis.
Referenceopen allclose all
Stability fo the test substance:
- after 1 minutes: peak area (GC) of the test item = 52.9733
- after 30 minutes: peak area (GC) of the test item = 42.8976
Description of key information
In contact with water the Sika Härter LJ will hydrolyse rapidly.
Key value for chemical safety assessment
Additional information
Non-submission justification:
Sika Härter LJ belongs to a class of polyaldimine compounds used as hardeners for polyurethane moisture hardening preparations. Upon contact with water, the hardening process is initiated and the hardener rapidly degrades. The hydrolysis products are Polyetheramin D230 (CAS No. 9046-10-0) and 2,2-Dimethyl-3-lauroyloxy-propanal (CAS No. 102985-93-3). According to non-GLP data from the manufacturer hydrolysis of Sika Härter LJ is acid catalysed. In order to assess the hydrolysis time different hydrolysis measurements (short term and long term) with flow injection analysis mass spectrometry (FIA-MS) were tested. A direct injection of the test item diluted in water free methanol into the FIA-MS, exposed to acetous and bidest. water, was performed for the short term measurement. The long term measurement contained the exposure of the test item with bidest water, acetous water and slightly carbonated water and the periodical recording of the FIMS measures. The results are as follows:
a) hydrolysis with acetous water (1% acetic acid): < 2 sec
b) hydrolysis with bidest. water: >> 2 sec
c) hydrolysis with acetous water as a function of time: < 5 min
d) hydrolysis with bidest. water as a function of time: ≥ 20 min
e) hydrolysis with slightly carbonated water as a function of time: < 20 min
Due to its use, Sika Härter LJ has a very limited stability in water as it needs to react rapidly upon contact with water.
Other information: data on hydrolysis of the hydrolysis product 2,2-Dimethyl-3-lauroyloxy-propanal (CAS No. 102985-93-3)
In the course of a study, in which the water solubility of the 2,2-Dimethyl-3-lauroyloxy-propanal was determined according to OECD guideline no. 105 and EU method A.16 the hydrolysis of the test substance was clearly observed. The test item reacted with oxygen-free water in approx. 60 minutes to products other than the carbon acid, the latter being a product of the reaction with oxygen. The appearance of new peaks in the GC-chromotograms indicated the appearance of degradation products due to hydrolysis.
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