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Diss Factsheets
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EC number: 941-360-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study and sufficiently documented; study acceptable as key study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Acetophenone
- EC Number:
- 202-708-7
- EC Name:
- Acetophenone
- Cas Number:
- 98-86-2
- Molecular formula:
- C8H8O
- IUPAC Name:
- 1-phenylethanone
- Details on test material:
- - Physical state: clear fluid
- Storage condition of test material: without special regulations
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner, Sulzfeld, Germany
- Weight at study initiation: males 110-135 g, females 100-120 g
- Fasting period before study: 16 hrs before substance application until 4 hrs post application
- Housing: 5 per cage
- Diet: ad libitum before and after treatment
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +- 1 °C
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1.0, 1.6, 2.5, 4.0 mL/kg corresponding to dosages of 1030, 1648, 2575, 4120 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical symptoms repeatedly on day of application, thereafter once daily; body weight on the day of application and on study day 7 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 081 mg/kg bw
- 95% CL:
- 1 597 - 2 730
- Mortality:
- Details of time course of death at the different tested doses are presented in Table 1
Except for 1 female rat of the highest dose group, all mortalities occurred within 24 hrs post application.
The LD50 was calculated at 2.02 mL/kg corresponding to 2,081 mg/kg with a 95% confidence interval of 1.55-2.65 mL/kg (1,597-2,730 mg/kg). - Clinical signs:
- other: Immediately after application all rats showed piloerection and bending Further dose-related effects: 1030 mg/kg: decreased motility 10/10, staggering gait 10/10; 1648 mg/kg: decreased motility 1/5 m, 1/5 f; staggering gait 1/5 m, 3/5 f; most a
- Gross pathology:
- Deceased animals: slight to severe hyperemia of the liver
Animals sacrificed at the end of the study: no pathological findings
Any other information on results incl. tables
Table 1: Time course of mortality findings
Time point | Controls | 1030 mg/kg | 1648 mg/kg | 2575 mg/kg | 4120 mg/kg | |||||
m | f | m | f | m | f | m | f | m | f | |
up to 6 hrs | 0/5 | 0/5 | 1/5 | 1/5 | 2/5 | 0/5 | 1/5 | 3/5 | 3/5 | 2/5 |
6 - 24 hrs | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 1/5 | 1/5 | 1/5 | 2/5 | 2/5 |
24 - 48 hrs | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
3 - 7 d | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 1/5 |
7 - 14 d | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Total mortality | 0/5 | 0/5 | 1/5 | 1/5 | 2/5 | 1/5 | 2/5 | 4/5 | 5/5 | 5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 in rats was 2,081 mg/kg bw. Death occurred within 24 hrs after application with unspecific clinical signs. Livers of deceased animals showed hyperemia.
- Executive summary:
The acute toxicity was investigated in groups of 5 male and 5 female Sprague-Dawley rats by gavage application of undiluted acetophenone. The oral LD50 in rats was 2081 mg/kg bw. Death occurred within 24 hrs after application with unspecific clinical signs. Livers of deceased animals showed hyperemia.
No tests are available with the substance Reaction mass of acetophenone and hydratropaldehyde and (E)-1,4-diphenyl-2-butene-1,4-dione. However, the main constituent Acetophenone is regarded as most relevant for the evaluation of the multi constituent substance. Therefore, the results of the test with Acetophenone were presented. The procedure laid down in the CLP regulation (1272/2008/EG) to base the classification and labeling on the available data and classification of the known main and relevant constituents was used. A detailed description of the evaluation used for this endpoint can be found in the "Endpoint summary" for "Acute toxicity". Based on this evaluation no further testing is indicated to be necessary.
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