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Diss Factsheets
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EC number: 200-424-8 | CAS number: 59-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Additional information
Source: National Toxicological Program, Technical Report Series No. 322. Toxicology and carcinogenesis studies of phenylephrine hydrochloride (CAS No. 61 -76 -7) in F344/N rats and B6C3F1 mice (feed studies).
Phenylephrine hydrochloride given to pregnant rabbits during the last third of gestation produced fetal growth retardation and the onset of early labor (Shabanah et al., 1969). The use of medications containing phenylephrine hydrochloride during the first 4 months of pregnancy was associated with a greater than expected number of eye, ear, and other minor malformations in humans (Heinonen et al., 1977). Two other epidemiologie studies found no association between congenital disorders and use of phenylephrine hydrochloride during pregnancy (Jick et al., 1981; Colley et al., 1982). ß-Sympathomimetic agents consistently caused external and cardiac malformations when administered to chick embryos, but phenylephrine hydrochloride did not cause similar defects (Hodach et al., 1975; Bruyere et al., 1983).
Toxicity to reproduction: other studies
Additional information
The briefly presented data above indicate some evidence of phenylephrine hydrochloride to be a contributory factor of fetal growth retardation and premature labor. However, due tu the restricted data presented in the underlying NTP document, no classification for developmental toxicity is proposed for phenylephrine hydrochloride.
No information is available of possible impairment of fertility through phenylephrine hydrochloride.
Justification for classification or non-classification
Based on the above presented data, no classification for reprotoxicity of phenylephrine hydrochloride is warranted.
Additional information
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