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EC number: 614-283-9 | CAS number: 68127-59-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-01 to 1984-04-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- animal room temperature slightly low (16°C); purity of the test material not reported.
- GLP compliance:
- yes
Test material
- Reference substance name:
- reaction mass of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid and (1S,3S)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid
- EC Number:
- 614-283-9
- Cas Number:
- 68127-59-3
- Molecular formula:
- C9H10ClF3O2
- IUPAC Name:
- reaction mass of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid and (1S,3S)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid
- Details on test material:
- - Physical state: crystalline powder
- Colour: white
- Expiration date of the lot/batch: not reported
- Storage condition of test material: not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 11 - 17 weeks
- Weight at study initiation: 3.43 - 3.75 kg
- Housing: individually in satinised aluminium sheet cages, 605 x 490 x 455 mm; floor: perforated aluminium sheet, door: Makrolon (polycarbonate)
- Water: tap water ad libitum, via an automatic system
- Acclimation period: >= 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx. 16°C, constantly recorded
- Humidity (%): approx. 55% relative, constantly recorded
- Air changes (per hr): 20 - 30
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: To: not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approx. 500 mg, moistened to a paste with water
- Test site: approx. 25 x 25 mm on the left flank of the animal
- Application: by disposable spatula
VEHICLE
- Amount applied (volume or weight with unit): 0.5 mL
- Purity: distilled - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 25, 45 and 69 hours after removal of dressing
- Number of animals:
- 6 females
- Details on study design:
- TEST SITE
- Area of exposure: 25 x 25 mm
- % coverage: not reported
- Type of wrap if used: a piece of surgical gauze (25 x 25 mm, 8-ply) covering the treated area was secured by two strips of surgical tape (12 x 100 mm), and covered with 0.5 mm rubber sheeting (350 x 135 mm), which was wrapped around the trunk and secured with adhesive polyethylene tape (450 x 75 mm).
REMOVAL OF TEST SUBSTANCE
- Washing: application site cleansed with swabs of absorbent cotton wool soaked in warm water, gently dried with tissue paper
- Time after start of exposure: 4 hours
SCORING SYSTEM:
- Draize scale, as in OECD 404
- Mean erythema and edema scores were calculated as the average of the 25-, 45- and 69-hour readings of all six animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: animal 7
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- other: animal 7
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- other: animal 8
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- other: animal 8
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- other: animal 23
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- other: animal 23
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- other: animal 24
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- other: animal 24
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- other: animal 46
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- other: animal 46
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- other: animal 47
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- other: animal 47
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Slightly irritant to rabbit skin, no corrosion observed . Erythema and edema reversible.
- Other effects:
- None observed
Any other information on results incl. tables
Table 1: Rabbit skin irritation
Erythema & edema: Draize scores for individual animals:
Erythema | Edema | |||||||
Animal no |
Hours after decontamination | Hours after decontamination | ||||||
1 | 25 | 45 | 69 | 1 | 25 | 45 | 69 | |
7 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
8 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
23 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
24 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
46 | 1 | 0 | 0 | 0 | 3 | 1 | 0 | 0 |
47 | 2 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Slight erythema and slight edema was caused by the test material on rabbit skin, 25 hours after the treatment (mean score 0.11, both for erythema and edema). The study report is relevant, reliable with restrictions and adequate for risk assessment, classification and labelling.
- Executive summary:
The acute skin irritation of the test material (a powder) was assessed according to a method similar to OECD 404 in six female New Zealand White rabbits. The test substance (0.5 g) was moistened with 0.5 mL deionized water and applied to the shaved skin (approx. 6 cm2), then covered with a gauze patch and semi-occlusive dressing for an exposure period of 4 hours. The application area was then cleansed with cotton wool swabs soaked in warm water, and dried with tissue paper. The degrees of erythema and edema were assessed at the following time points: 1, 25, 45, and 69 hours after the removal of the patch, according to the Draize scale. Mean erythema and edema scores were calculated from the readings at 25, 45, and 69 hours.
Very slight to well-defined erythema, and very slight to moderate edema were observed after 1 hour; these findings were still seen in only 2/6 animals at 25 hours, and completely disappeared at 45 hours. From the numerical scores of the individual animals at 25, 45, and 69 hours, the averages for erythema and edema were calculated to be 0.11 each.
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