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EC number: 941-221-0 | CAS number: 203929-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 January 2012 to 28 January 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not conducted in compliance with GLP regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- MTDID 30531
- IUPAC Name:
- MTDID 30531
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): MTDID 30531
- Substance type: Mono-constituent
- Physical state: Liquid
- Analytical purity: 98.5%
- Purity test date: 01 October 2012
- Lot/batch No.: IOFH-AH221-ANL1200052
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Portage, MI
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 186-200 g
- Fasting period before study: None
- Housing: group housed in standard solid-bottom plastic cages with bedding
- Diet (e.g. ad libitum): Harlan Teklad Rat/Mouse 2018 Diet (Harlan Teklad, Madison, WI) ad libitum
- Water (e.g. ad libitum): Tap Water ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.6-23.9
- Humidity (%): 30-70
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 14 January 2012 To: 28 January 2012
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 40 liter plexiglass chamber mixed by means of a recirculating pump connected to opposite sides of the chamber via a loop of stainless steel tubing.
- Exposure chamber volume: 40 liters
- Method of holding animals in test chamber: Animals were whole body exposed whithin the chamber
- Source and rate of air: No data
- Method of conditioning air: No data
TEST ATMOSPHERE
- Brief description of analytical method used: Exposure chamber test article concentrations were measured approximately every 5 minutes during each exposure period using a gas chromatographic-electron capture detector (GC-ECD) method. Samples were taken from the recirculating airstream.
- Samples taken from breathing zone: Samples were taken from the recirculating airstream. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 0, 91.0, and 862.9 ppm
- No. of animals per sex per dose:
- 3 males per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations (during, immediately after, and 2 hours following exposure, daily thereafter) and body weights (Days 1, 8 and 15) were noted.
- Necropsy of survivors performed: yes/no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 6.25 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- All animals survived to scheduled necropsy.
- Clinical signs:
- other: Animals in the 863 ppm (12.49 mg/L, vapor) group exhibited slightly increased activity, slight ataxia, and in one animal occasional gasping during exposure. Animals in the 91 ppm (1.32 mg/L, vapor) group exhibited slightly increased respiration rates duri
- Body weight:
- Body weight gains were normal in all animals.
- Gross pathology:
- No gross lesions were observed in any animals at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, the 4 -hour equivalent LC50 of the test article is greater than 431.5 ppm (6.25 mg/L, vapor).
- Executive summary:
The acute inhalation toxicity of the test article (Clear and colorless to pale pink liquid, Purity 98.2%, Lot: IOFH-AH221-ANL1200052) was evaluated in Sprague Dawley rats. The study was not conducted under GLP conditions. The test method was based OECD Guideline 403 (1981). The test article was administered as a vapor. Male rats (3/group) were exposed, whole body, to the test article at 91 ppm (equivalent dose 1.32 mg/L) or 863 ppm (equivalent dose 12.49 mg/L) and for a single, 1 hour exposure. Clinical observations (for 2 hours after exposure and daily thereafter) and body weights (prior to exposure and on Days 8 and 15) were recorded. Limited necropsy was performed on all animals on Day 15, no organs or tissues were collected. All animals survived to scheduled necropsy. Animals in the 863 ppm group exhibited slightly increased activity, slight ataxia, and in one animal occasional gasping during exposure. Animals in the 91 ppm group exhibited slightly increased respiration rates during exposure. Clinical signs post-exposure were normal in all animals. Body weight gains were normal in all animals. No gross lesions were observed in any animals at necropsy. Based on the results of the study, the 4-hour equivalent LC50 of the test article is great than 431.5 ppm (6.25 mg/L, vapor).
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