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EC number: 941-221-0 | CAS number: 203929-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An acute inhalation toxicity was conducted on IOFH. The result of the study was:
The rat inhalation LC50 is greater than 431.5 ppm (6.25 mg/L, vapor) when tested according to OECD 403.
Key value for chemical safety assessment
Additional information
The acute inhalation toxicity of the test article (Clear and colorless to pale pink liquid, Purity 98.2%, Lot: IOFH-AH221-ANL1200052) was evaluated in Sprague Dawley rats. The study was not conducted under GLP conditions. The test method was based OECD Guideline 403 (1981). The test article was administered as a vapor. Male rats (3/group) were exposed, whole body, to the test article at 91 ppm (equivalent dose 1.32 mg/L) or 863 ppm (equivalent dose 12.49 mg/L) and for a single, 1 hour exposure. Clinical observations (for 2 hours after exposure and daily thereafter) and body weights (prior to exposure and on Days 8 and 15) were recorded. Limited necropsy was performed on all animals on Day 15, no organs or tissues were collected. All animals survived to scheduled necropsy. Animals in the 863 ppm group exhibited slightly increased activity, slight ataxia, and in one animal occasional gasping during exposure. Animals in the 91 ppm group exhibited slightly increased respiration rates during exposure. Clinical signs post-exposure were normal in all animals. Body weight gains were normal in all animals. No gross lesions were observed in any animals at necropsy. Based on the results of the study, the 4-hour equivalent LC50 of the test article is great than 431.5 ppm (6.25 mg/L, vapor).
Justification for classification or non-classification
The test article meets the CLP classification criteria for Acute Toxicity Category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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