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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In a reliable GLP study, the test item caused mortalities in the range of 20 to 95% tested with the solid content concentrations of 6.28 -50.2 mg/L. The 96h-LC50 was 26.6 mg/L (expressed as solid content of the test item, nominal) and the 96h-LC0 was < 6.28 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 26.6 mg/L
Additional information
The acute toxicity of the test item Dermalcare MAP L-213/S on embryonic stages of zebrafish (Danio rerio) was determined according to OECD guideline 236 and in compliance with GLP.
The 96–hour acute toxicity was studied under semi-static conditions (with daily renewal of test medium) with the nominal concentrations of 12.5 – 25.0 – 50.0 – 100 – 200 mg/L (corresponding to the solid content concentrations of Dermalcare MAP L-213/S: 3.14 – 6.28 – 12.6 – 25.1 – 50.2 mg/L).
Fish eggs were exposed to each concentration level of test item and to the reference item 3.4-dichloroaniline (at 4 mg/L). In parallel, a control plate and internal controls in each tested plate were used. Mortality was determined observing every days the following biological parameters: coagulation of embryos, absence of somite formation, non-detachment of the tail and lack of heart-beat.
The 96h-LC50 was 26.6 mg/L (expressed as solid content of the test item, nominal) and the 96h-LC0 was < 6.28 mg/L. In the plate of the lowest tested concentration (12.5 mg/L), 2 dead embryos were observed on the internal control. Thus the plate had to be rejected and its results were not included in the evaluation. Moreover, the water parameters were within the acceptable limits and the validity criteria of the guideline were fulfilled.
Based on the results of this study, Dermalcare MAP L-213/S is considered as harmful to fish.
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater fish.
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